Registration Dossier
Registration Dossier
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EC number: 276-017-4 | CAS number: 71786-67-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- see attached study report
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Benzyl(3-hydroxyphenacyl)methylammonium chloride
- EC Number:
- 276-017-4
- EC Name:
- Benzyl(3-hydroxyphenacyl)methylammonium chloride
- Cas Number:
- 71786-67-9
- Molecular formula:
- C16H17NO2.ClH
- IUPAC Name:
- benzyl(3-hydroxyphenacyl)methylammonium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Chbb:THOM ( SPF )
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. K. Thomae , Biberach/Riß
- Age at study initiation: male 50 - 51 d ; female 55 - 56 d
- Weight at study initiation ( mean ) : male 193.6 g ; female 174.0 g
- Fasting period before study: 16 - 20 h
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 - 26 °C
- Humidity (%): 50 -65 %
- Photoperiod (hrs dark / hrs light): 12 : 12 , light 6:00 - 18:00
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Tween 80
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 mL/kg BW
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg - Doses:
- 3160 mg/kg
5000 mg/kg - No. of animals per sex per dose:
- 5 female per dose
5 male per dose - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations : 1 -2 x
- Necropsy of survivors performed: yes
- Other examinations performed: body weight,histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 female and 1 male
dose : 5000 mg/kg
11 min and 20 min after application - Clinical signs:
- other: 1 female and 1 male dose : 3160 mg/kg Ataxia, face-down and lateral position , Exophthalmia end after ca. 30 min nearly all animals dose : 5000 mg/kg Ataxia, face-down and lateral position , Exophthalmia end after first day of application
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information
- Conclusions:
- Due to the LD50 > 5000 mg/kg it is assumed that Benzyladrianon hydrchlorid is slightly toxic.
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