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EC number: 203-818-8 | CAS number: 110-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No data on toxicokinetics, metabolism and distribution are available for N, N, N', N'-tetramethyltrimethylenediamine. Based on its physico-chemical properties, N, N, N', N'-tetramethyltrimethylenediamine is expected to be well absorbed by the respiratory and gastro-intestinal tracts and through the skin.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
There is no toxicokinetics, metabolism and distribution data available on N, N, N', N'-tetramethyltrimethylenediamine (TMPDA). Therefore, the assessment of the toxicokinetics of TMPDA is based on the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c:
Molecular weight: 130.23 g/mole
Water solubility: 598 g/L at 25°C
Partition coefficient log Kow = 0.29
ABSORPTION
Oral route
According to the REACH Guidance, the physicochemical characteristics of TMPDA (log Kow = 0.29) and the molecular mass (130.23 g/mol) are in a range suggestive of absorption as such from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is supported by the mortality and the clinical signs observed in the acute oral toxicity study in rats from the dose level of 312 mg/kg bw and upward (BASF, 1974). Therefore, the oral absorption of TMPDA is assumed to be 100% for risk assessment.
Inhalation route
According to the REACH Guidance, the physicochemical characteristics of TMPDA (log Kow = 0.29) and the molecular mass (130.23 g/mol) are in a range suggestive of absorption as such from the respiratory tract subsequent to an inhalation exposure. This assumption of inhalation absorption is supported by the mortality observed in the acute inhalation toxicity studies (Smyth et al., 1969; BASF, 1974). Therefore, the inhalation absorption of TMPDA is assumed to be 100% for risk assessment.
Dermal absorption
According to the REACH Guidance, the n-Octanol/water partition coefficient (log Kow), the water solubility and molecular weight of TMPDA are in ranges which favour dermal absorption. This assumption of dermal absorption is supported by the mortality observed in the acute dermal toxicity studies (Smyth et al., 1969; BASF, 1982). In such circumstances, a default value of 100% skin absorption is generally used.
DISTRIBUTION and METABOLISM
According to the REACH Guidance, as a small molecule a wide distribution of TMPDA is expected.
The metabolism of most simple aliphatic tertiary amines proceeds through biological oxidation of the amine to an amine oxide.
ELIMINATION
As tertiary amine oxides are stable and water soluble, they are filtered by the kidney and undergo primarily urinary excretion.
According to the REACH Guidance, the n-Octanol/water partition coefficient is not suggestive of accumulation of unchanged TMPDA in fatty tissues subsequent to absorption.
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