Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 454-830-7 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
- Principles of method if other than guideline:
- Test procedure:
Ligne directrice OCDE 429.
Results and discussion
- Details on results:
- Mortalité et signes cliniques:
Aucune mortalité et aucun signe clinique ne sont observés
pendant l'étude.
Irritation locale:
Une coloration jaune des oreilles ayant pu masquer un
érythème très léger est observé aux jours 2, 3 et 6 chez la
plupart des animaux ayant reçu la substance à la
concentration de 10 ou 25 %.
Une légère augmentation de l'épaisseur de l'oreille est
observée à la concentration de 25 %.
Aucune augmentation notable de l'épaisseur de l'oreille
n'est notée aux autres concentrations testées.
Potentiel sensibilisant:
Une augmentation dose-reliée des index de stimulation
est observée et la valeur seuil positive de 3 est
dépassée à toutes les concentrations testées.
En l'absence d'irritation locale, les réponses
lymphoprolifératives observées aux concentrations
inférieures à 25 % sont attribuées à de l'hypersensibilité
cutanée retardée.
La valeur de l'EC3 obtenue pour la substance est inférieure
à 1 %. (concentration à partir de laquelle l'indice de
stimulation est > 3).
Indice de stimulation :
10 à 1 %
20.08 à 2.5 %
25 à 5 %
36 à 10 %
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
