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EC number: 201-051-3 | CAS number: 77-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The collected experimental data suggest that the substance does not meet the criteria for acute toxicity classification either for oral or dermal route of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Identity: 5,5-Dimethylhydantoin (CAS RN 77-71-4)
Purity: No information provided - Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 8 430 mg/kg bw
- Clinical signs:
- other: The following linical signs were reported: LUNGS, THORAX, OR RESPIRATION: dyspnea BEHAVIORAL: withdrawal, somnolence (general depressed activity)
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 for 5,5-Dimethylhydantoin was determined to be 8430 mg/kg in guinea pig.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Identity: 5,5-Dimethylhydantoin (CAS RN 77-71-4)
Purity: No information provided - Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 12 660 mg/kg bw
- Clinical signs:
- other: The following effect were reported: LUNGS, THORAX, OR RESPIRATION: dyspnea BEHAVIORAL: somnolence (general depresses activity), regidity
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 for 5,5-Dimethylhydantoin was determined to be 12660 mg/kg in rabbit.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Identity: 5,5-Dimethylhydantoin (CAS RN 77-71-4)
Purity: No information provided - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 7 800 mg/kg bw
- Clinical signs:
- other: The following effect were reported: LUNGS, THORAX, OR RESPIRATION: dyspnea BEHAVIORAL: withdrawal, somnolence (general depressed activity)
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 for 5,5-Dimethylhydantoin was determined to be 7800 mg/kg in rat.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 7 000 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Identity: 5,5-Dimethylhydantoin (CAS RN 77-71-4)
Purity: No information provided - Species:
- mouse
- Strain:
- New Zealand White
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- The route of exposure specified is the subcutaneous one. As a conservative assumption the subcutaneous route was use for the evaluation of the acute dermal toxicity of the substance.
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The route of exposure specified is the subcutaneous one. As a conservative assumption, the subcutaneous route was used for the evaluation of the acute dermal toxicity of the substance.
The acute dermal LD50 for 5,5-Dimethylhydantoin was determined to be 2800 mg/kg in mouse.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 800 mg/kg bw
Additional information
Justification for classification or non-classification
The substance does not meet the criteria for acute toxicity classification for either oral or dermal route of exposure.
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