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EC number: 225-533-8 | CAS number: 4904-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Method: see reference
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclododeca-1,5,9-triene
- EC Number:
- 225-533-8
- EC Name:
- Cyclododeca-1,5,9-triene
- Cas Number:
- 4904-61-4
- Molecular formula:
- C12 H18
- IUPAC Name:
- cyclododeca-1,5,9-triene
- Reference substance name:
- 1,5,9-Cyclododecatriene
- IUPAC Name:
- 1,5,9-Cyclododecatriene
- Details on test material:
- purity: 99.8%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Crl:CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Strain: Crl:CD
- Controls: no
Administration / exposure
- Route of administration:
- inhalation: mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- ADMINISTRATION:
- Type of exposure: whole body
- Concentrations: 5; 6; 7; 8; 8.5; 9; 10 mg/l (nominal)
- Particle size: no data
- Type or preparation of particles: spray nozzle with precision liquid metering pump
- Post observation period: 14 days - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Concentrations:
- 5; 6; 7; 8; 8.5; 9; 10 mg/l (nominal)
- No. of animals per sex per dose:
- 10 (except 8 mg/l and 10 mg/l: 20 per group)
- Control animals:
- no
- Details on study design:
- EXAMINATIONS:
- throughout exposure period: Clinical signs and mortality
- 14 day recovery: Body weights examined and gross autopsy of all animals - Statistics:
- LC 50 and 95% confidence interval calculated statistically
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 8.2 mg/L air
- 95% CL:
- >= 7.5 - <= 8.9
- Exp. duration:
- 6 h
- Mortality:
- MORTALITY:
- Time of death: 92 % during exposure (8% latent mortality)
- Number of deaths at each dose:
mg/l: 5.0; 6.0; 7.0; 8.0; 8.5; 9.0; 10.0
dead: 0/10; 1/10; 5/10; 5/20; 4/10; 3/10; 18/20 - Clinical signs:
- other: MAJOR CLINICAL SIGNS: gasping, twitching, and severe muscle spasms, tonic convulsions. In general, recovery of the animals was complete by the third day following exposure.
- Gross pathology:
- MAJOR NECROPSY FINDINGS: Distention of all or portions of the gastrointestional tracts and cyanosis of the exposed body surfaces were the major gross findings at autospsy of the animals which died. Gross appearance of the organs of the surviving animals was normal.
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study it is concluded that the LC50 for male rats is 8.2 mg/l (95% confidence interval = 7.5 - 8.9) mg/l for the test item 1,5,9-cyclododecatriene.
- Executive summary:
Male rats were exposed whole body for a single, 6 hour periode to vapors of the test item 1,5,9-cyclododecatriene in air at chamber vapor concentrations of 5.0, 6.0, 7.0, 8.0, 8.5, 9.0 and10.0 mg/l. Mortality was 0/10; 1/10; 5/10; 5/20; 4/10; 3/10; 18/20 within the exposure groups (5.0, 6.0, 7.0, 8.0, 8.5, 9.0 and10.0 mg/l) and 92 % died during exposure.
Clinical signs noted in rats from all exposures included gasping, twitching, and severe muscle spasms. In general, recovery of the animals was complete by the third day following exposure. Under the conditions of the study it is concluded that the LC50 for male rats is 8.2 mg/l (95% confidence interval = 7.5 - 8.9) mg/l for the test item 1,5,9-cyclododecatriene.
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