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Diss Factsheets
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EC number: 946-354-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: read-across from constituent CrIII
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Tolerance of Fundulus heteroclitus to different metals in saltwater
- Author:
- Dorfman D
- Year:
- 1 977
- Bibliographic source:
- ull New Jersey Acad Sci 22:21-23.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Test was performed with saltwater species
- GLP compliance:
- no
Test material
- Reference substance name:
- Cr III
- Molecular formula:
- Cr III
- IUPAC Name:
- Cr III
- Details on test material:
- CrCl3.6H2O or CrCl3
1
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- No details given
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Serial dilutions of the metals ion concentrations: 0, 10, 100 and 1000 mg/L.
Test organisms
- Test organisms (species):
- Fundulus heteroclitus
- Details on test organisms:
- Fish were collected with seines from waters with salinities in excess of 17 ppt.
The collection areas, all in New Jersey, included Shark River, Shrewsbury River and Horseshoe Cove at Sandy Hook. They were acclimated in the laboratory for at least three days prior to testing in plastic tubs in either waters of low salinities (3 to 8 ppt) or high salinities (17 to 23 ppt).
Waters for fish maintenance and subsequent assays were obtained from either Horseshoe Cove or from the ocean of Asbury Park, New Jersey. These waters were diluted to the salinity ranges (low or high) with aged tap water.
Study design
- Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- Evaluation of mortality at 24, 48, 72 and 96 h.
- Post exposure observation period:
- not reported
Test conditions
- Hardness:
- not reported
- Test temperature:
- ca. 20°C
- pH:
- not reported
- Dissolved oxygen:
- not reported
- Salinity:
- low salinity: for chromium chloride 6.1 ppt
high salinity: for chromium chloride 24.0ppt - Nominal and measured concentrations:
- nominal concentration given as metal ion Cr(III): 0, 1, 10, 100 and 1000 mg/L
- Details on test conditions:
- For the assays glass 3.7 liter vessels were filled with salt waters obtained directly from either the low or high salinity fish acclimation tanks. Serial dilutions of the metals used in the assays were made in the following concentrations (of the metal ion), 1000, 100, 10, 1 and 0 mg/L. Additional dilutions of 0.1, 0.01 and 0.001 mg/L were added for mercury. Nine fish, selected at random, were exposed in each concentration, with three fish per vessel. Tests were performed in both low and high salinities. These were completed during May and June, 1976. Tests in which more than one control fish expired were repeated. Fish were maintained and tested at 20 °C. Natural-lighting allowed a normal day-night regime. Fish weights (average wet weight was 2.7 g, range 1.1 - 6.0) were recorded at the completion of each test. Tolerance level 50s (TL50 - the level at which 50 percent of the test organisms survive) for each metal for 24, 48, 72 and 96 hours at low and high salinities were obtained by straight-line graphical interpolation.
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 31.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: Cr III ion
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: identical LC50 was obtained with high salinity (24 ppt) and low salinity (6.1 ppt) respectively
- Details on results:
- The LC50 was 31.5 mg/L after 24, 48, 72 and 96 h, independent of salinity (low: 6.1 and high: 24.0 ppt). Tthe dominant effect for toxicity was concluded to be the reduction of pH.
Applicant's summary and conclusion
- Conclusions:
- For chromium chloride a LC50 (96h) of 31.5 mg Cr/L (equivalent to 96 mg CrCl3/L or 161 mg CrCl3.6H2O/L) was obtained for Fundulus heteroclitus.
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