Registration Dossier
Registration Dossier
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EC number: 820-225-5 | CAS number: 101747-77-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Source substance Phosphorodithioic acid, mixed O,O-bis(1,3 -dimethylbutyl and iso-Pr) esters, zinc salts (CAS 84605 -29 -8):
The acute toxicity of the test material to the freshwater fish Oncorhynchus mykiss was investigated under GLP according to OECD guideline 203 in a Klimisch-2 study and resulted in a 96 hour LL50 of 4.5 mg/L (95% confidence limits of 3.5 to 5.7 mg/L) and a NOEL of 1.8 mg/L.
Source substance Zinc bis(O,O-diisobutyl dithiophosphate) (CAS 68457 -79 -4):
The acute toxicity of the test material to the saltwater fish Cyprinodon variegatus was investigated under GLP according to OECD guideline 203 in a Klimisch-2 study and resulted in a 96 hour LC50 of 46 mg/L. A reference toxicity test was conducted with sodium lauryl sulfate resulting in a 96 hour LC50 of 1.3 mg/L.
Source substance Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259 -15 -8):
The acute toxicity of the test material to the freshwater fish Oncorhynchus mykiss was investigated under GLP according to OECD guideline 203 in a Klimisch-2 study and resulted in a 96 hour LL50 of 4.4 mg/L (95% confidence limits of 4.4 to 4.6 mg/L) and a NOEL of 3.2 mg/L
The LL50 -values for the acute toxicity to freshwater fish are slightly differing (4.5 & 4.4 mg/L), but this is in range with the category approach, where nevertheless the members of one category may have different values.
For CSA the lower value is choosen as worst-case-approach .
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 4.4 mg/L
Marine water fish
Marine water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 46 mg/L
Additional information
The key value for the CSA for freshwater fish is stated as LL50, not as LC50!
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