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Diss Factsheets
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EC number: 293-434-7 | CAS number: 91079-46-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-04-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Decomp. temp.:
- >= 120 °C
- Conclusions:
- The substance decompose at 120 °C before melting.
- Executive summary:
A study was conducted according to OECD test guideline 102, Regulation (EC) No 440/2008 method A.1 and EPA OCSPP test guideline 830.7200 to determine the melting point of the test item using differential scanning calorimetry. The test item was weighed out into an aluminium crucible under an inert atmosphere (nitrogen). Two tests with about 5 – 6 mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. The substance is a solid at ambient conditions. In the temperature range of 50 – 80 °C, a small endothermic effect was observed. Between 120 – 180 °C an exothermic effect could be detected, with a mean energy of 30 J/g. For a verification of the DSC measurement the capillary method was performed. The test item changed its colour from light yellow to yellow at a temperature of 103.8 °C and ascended in the capillary to the top at 124.9 °C. At 141.5 °C the color of the test item changed to brown and at 162.3 °C to black. No melting of the test item could be observed. It was concluded that the test item started to decompose at approx. 120 °C.
Reference
Melting and Boiling Point (DSC)
In the temperature range of 50 – 80 °C, a small endothermic effect was observed. Between 120 – 180 °C an exothermic effect could be detected, with a mean energy of ‑30 J/g.
In the temperature range of 400 – 430 °C a second endothermic effect occurred, directly followed by a second exothermic effect, with a mean energy of -160 J/g.
Sample weight / mg |
Onset of Effect / °C |
Range of effect / °C |
Weight loss / mg |
Atmospheric pressure / hPa |
4.58 |
51.83 |
50 – 80 (endo) |
3.64 |
998.4 |
6.44 |
46.49 |
50 – 80 (endo) 400 – 430 (endo) |
3.98 |
1000.0 |
For a verification of the DSC measurement the capillary method was performed. The test item changed its color from light yellow to yellow at a temperature of 103.8 °C and ascended in the capillary to the top at 124.9 °C. At 141.5 °C the color of the test item changed to brown and at 162.3 °C to black. No melting of the test item could be observed. Combining the results of the DSC measurements and of the capillary method, none of the endothermic effects can be assigned to the melting of the test item. The test item started to decompose at approx. 120 °C.
Description of key information
The substance decompose at 120 °C before melting.
Key value for chemical safety assessment
Additional information
The substance as an UVCB consisting of different peptides. Peptides are known to denaturate at non-physiological temperatures, i. e. beyond 60 °C or even less (H. Robert Horton et al.: Biochemie. Pearson Deutschland GmbH, 2008, ISBN 978-3-827-37312-0, S. 144–146). Secondary and tertiary structures are crucial regarding the peptides function and visual appearence. They are mainly configured by non-covalent bonds such as hydrogen bonds or van der waals forces. These bonds become destroyed and/or altered at elevated temperatures. Consequntley, denatured peptides lose their native 3D-structure and with this their functionality.
In order to support the above consideration, a study was conducted according to OECD test guideline 102, Regulation (EC) No 440/2008 method A.1 and EPA OCSPP test guideline 830.7200 to determine the melting point of the test item using differential scanning calorimetry (reference 4.2 -1). The test item was weighed out into an aluminium crucible under an inert atmosphere (nitrogen). Two tests with about 5 – 6 mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. The substance is a solid at ambient conditions. In the temperature range of 50 – 80 °C, a small endothermic effect was observed. Between 120 – 180 °C an exothermic effect could be detected, with a mean energy of 30 J/g. For a verification of the DSC measurement the capillary method was performed. The test item changed its colour from light yellow to yellow at a temperature of 103.8 °C and ascended in the capillary to the top at 124.9 °C. At 141.5 °C the color of the test item changed to brown and at 162.3 °C to black. No melting of the test item could be observed. It was concluded that the test item started to decompose at approx. 120 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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