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Diss Factsheets
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EC number: 258-887-7 | CAS number: 53956-04-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
See "Justification for Classification"
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- peer-reviewed monograph
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not specified, methods can be inferred from the results
- GLP compliance:
- not specified
- Test type:
- other: Test type not provided
- Limit test:
- no
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 12 700 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item has a very low acute toxicity (oral) with an LD50 of 12700 mg/kg in mice.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Remarks:
- no information in the publication
- Test type:
- other: Test type not provided
- Limit test:
- no
- Species:
- other: rats and mice
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 18 other: g/kg
- Based on:
- not specified
- Remarks on result:
- other: Rats
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 14.2 other: g/kg
- Based on:
- not specified
- Remarks on result:
- other: Rats
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7.5 other: g/kg
- Based on:
- not specified
- Remarks on result:
- other: Mice
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Licorice extract (53% glycyrrhizin, containing Ammonium glycyrrhizinate) LD50 is 18 g/kg in male rats, 14.2 g/kg in female rats, and >7.5 g/kg in mice.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 12 700 mg/kg bw
Additional information
Justification for classification or non-classification
Acute oral toxicity : two secondary citations are available from publications with limited details on methods and test item (both Klimisch 4):
- Ammonium glycyrrhizinate LD50 is 12.7 g/kg bw in mice.
- Licorice extract (53% glycyrrhizin, containing Ammonium glycyrrhizinate) LD50 is 18 g/kg in male rats, and 14.2 g/kg in female rats. In mice, the DL50 is greater than 7.5 g/kg.
Although one of the reports used for the acute toxicity oral assessment was made on the basis of glycyrrhizin rather than on pure ammonium glycyrrhizate (both being licorice constituents), and despite the lack of information about the test methods, overall these values are good indicators of an extremely low ammonium glycyrrhizate acute oral toxicity.
The fixed value in mice (12.7 g/kg) is kept as a worst-case, after eliminating the lower-limit value in mice (>7.5 g/kg).
No classification is needed according to both CLP and GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.