Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-150-3 | CAS number: 156572-81-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Desmodesmus subspicatus CHODAT (SAG 86.81) from the SAG Culture Collection at the University Göttingen
- Test type:
- static
- Water media type:
- freshwater
- Test temperature:
- 22.8 to 23.3°C.
- pH:
- 7.1-7.5
- Nominal and measured concentrations:
- 100,50,25,12.5,6.25mg/l
- Details on test conditions:
- Light intensity is continuously variable and was set on 45% of the maximum light intensity resulting in a mean light intensity of 120 μE/m2 s +/- 3.6% (PAR, measured by a spherical sensor).
- Reference substance (positive control):
- yes
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 46.3 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 20.4 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 12.5 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth rate
- Details on results:
- During the test course ISELUX was stable. Recovery rate was determined between 97.3% and 101.7%.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a study according to OECD 201, SLMI has a EC50 of 46.3 mg/L (Growth Rate) and a NOEC of 12.5mg/L
Reference
Description of key information
In a study performed according to OECD 201, SLMI has a EC50 of 46.3 mg/L (Growth Rate) and a NOEC of 12.5mg/l
In a study performed to EPA OPPTS 850.5400, on the read across material SCMI, a NOEC of <0.1 mg/L and an LC50 of >1000 mg/L based on cell number (nominal concentrations) was achieved
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 46.3 mg/L
- EC10 or NOEC for freshwater algae:
- 12.5 mg/L
Additional information
In a key study performed according to OECD 201, SLMI has a EC50 of 46.3 mg/L (Growth Rate) and a NOEC of 12.5mg/l.
In a supporting study performed to EPA OPPTS 850.5400, on the read across material SCMI, a NOEC of <0.1 mg/L and an LC50 of >1000 mg/L based on cell number (nominal concentrations) was achieved
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
