Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Available data regarding the effects of cadmium compounds on human health has been carefully reviewed and scrutinised in the framework of the discussions on the EU Risk Assessment Report (RAR) developed according to EU Regulation 793/93/EEC, with a focus on cadmium metal and cadmium oxide (ECB, 2007)
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
secondary source
Title:
European Union Risk Assessment Report: cadmium metal. Part II: human health. Vol 74.
Author:
ECB- Joint Research Center (JRC)
Year:
2007
Bibliographic source:
ECB (2007). European Union Risk Assessment Report: cadmium metal. Part II: human health. Vol 74.

Materials and methods

Principles of method if other than guideline:
experimental , no further information
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cadmium oxide
EC Number:
215-146-2
EC Name:
Cadmium oxide
Cas Number:
1306-19-0
Molecular formula:
CdO
IUPAC Name:
oxocadmium

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
63 mg/kg bw
Mortality:
no information
Clinical signs:
other: no information

Applicant's summary and conclusion

Interpretation of results:
other:
Remarks:
Criteria used for interpretation of results: expert judgment
Executive summary:

The EU risk assessment, as a secondary reference, cites data reported by WHO (1992) and CEC (1978) (secondary references).

LD 50 values were derived from studies in rats and mice using CdO administered orally or intra-gastrically but details on the primary studies reporting these values are not available. LD50 value was 63mg Cd/kg bw in the mouse.