Registration Dossier
Registration Dossier
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EC number: 204-072-6 | CAS number: 115-21-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- no data
- Type of information:
- other: HSDB
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original sources are traceable.
Data source
Reference
- Reference Type:
- other: HSDB
- Title:
- Trichloroethylsilane CASRN: 115-21-9
- Author:
- HSDB
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trichloro(ethyl)silane
- EC Number:
- 204-072-6
- EC Name:
- Trichloro(ethyl)silane
- Cas Number:
- 115-21-9
- Molecular formula:
- C2H5Cl3Si
- IUPAC Name:
- trichloro(ethyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Trichloroethylsilane
- Substance type: CHLORO-Si (TRI-Cl)
- Physical state: colourless liquid
- Storage condition of test material: To be stored in a cool, well ventilated location. Separate from acids, alkalines, oxidizing materials and water.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
Results and discussion
In vivo
- Other effects:
- Severe burns, with complete denaturation and tissue sloughing, may occur within two to three minutes after exposure.
The data source describes chlorosilanes as very corrosive to skin and mucous membranes as they liberate hydrochloric acid in the presence of water.
When applied to the skin of rabbit, the region attacked by chlorosilanes blanches and blisters appear; the action is more marked the damper the surface of skin is.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The data source describes the test substance as very corrosive to skin and mucous membranes, based on a collection of relaible data which has been subject to peer review and in which the original data sources are traceable. The result is considered to be reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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