Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-230-3 | CAS number: 17185-29-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 404)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The humidity went down to 30% “for a short period; this deviation was without any influence on the results of the study”. Also, the patch was occluded, rather than semi-occluded.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Carbonylhydrotris(triphenylphosphine)rhodium
- EC Number:
- 241-230-3
- EC Name:
- Carbonylhydrotris(triphenylphosphine)rhodium
- Cas Number:
- 17185-29-4
- Molecular formula:
- C55H46OP3Rh
- IUPAC Name:
- carbonylhydrotris(triphenylphosphine)rhodium
- Details on test material:
- Name of test material (as cited in study report): Carbonylhydridotris(triphenylphosphane)-rhodium(I)
- Substance type: yellow powder
- Physical state: solid
- Analytical purity: >99%
- Impurities (identity and concentrations): not stated
- Composition of test material, percentage of components: not stated
- Isomers composition: not stated
- Purity test date: not stated
- Lot/batch No.: FM 36/4/90
- Expiration date of the lot/batch: not stated
- Stability under test conditions: stable
- Storage condition of test material: closed container room temperature
- Other:
- Purity test method: Gravimetric Rh - analysis
- Solubility: insoluble in water and n-hexane; soluble in chloroform at 1 g/60 ml, soluble in acetone at 1 g/100 ml
- pH: ~7
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: White Russian (Albino)
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: ASTA Pharma AG
- Age at study initiation: 7-12 months
- Weight at study initiation: 2.59-2.77 kg
- Housing: Stainless steel cages with grating floor, size 48.5 cm(l) x 40 cm (b) x 36.5 cm (h); 1/cage
- Diet (e.g. ad libitum): Standard diet, Ssniff K, special diet for rabbits; ~120 g/day per animal
- Water (e.g. ad libitum): municipal drinking water, automatic drinking water system with drinking nipples; ad libitum
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22.5
- Humidity (%): 30-70
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: not stated
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: control area on opposite flank of each treated animal
- Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): not applicable, moistened
VEHICLE
- Amount(s) applied (volume or weight with unit): not applicable, enough to moisten test material
- Concentration (if solution): not applicable, moistened
- Lot/batch no. (if required): not applicable
- Purity: demineralised water- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after patch removal (all 3 animals), then daily to day 6 (1 animal)
- Number of animals:
- 3
- Details on study design:
TEST SITE
- Area of exposure: ~6.25 cm2
- % coverage: not stated
- Type of wrap if used: site of application covered with linen cloth which adhered to a synthetic film glue; bandage wrapped several times around the trunk providing complete occlusion
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, at end of exposure period
- Time after start of exposure: 4 hours
SCORING SYSTEM: Qualitative and quantitative assessment using Draize method - erythema/eschar and oedema, both scored on a scale of 0-4; also occurrence of further reactions of the skin (e.g. corrosive effects) and clinical signs (indicating systemic toxicity)
Irritation index calculated from sum of mean values of individual scores at the 4 observation times for erythema/eschar and for oedema; graded using modification of the method of Gilman et al., 1983
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: All time points: 1, 24, 48 and 72 hours, 4 and 6 days
- Score:
- ca. 0
- Max. score:
- 8
- Irritant / corrosive response data:
- Erythema/eschar: 0 at all time points in all animals
Oedema: 0 at all time points in all animals.
Corrosion: no effects noted
Corresponding control patch on opposite flank of each animal: no reactions - Other effects:
- No systemic effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a guideline study, to GLP, carbonylhydridotris(triphenylphosphane)-rhodium(I) was not irritating to the skin of rabbits following a 4-hr occlusive application.
- Executive summary:
The skin irritation potential of carbonylhydridotris(triphenylphosphane)-rhodium(I) was evaluated in White Russian rabbits in a study conducted according to OECD Test Guideline 404 and to GLP.
The test material (0.5 g, moistened with water) was applied to the shaved dorsal skin of 3 animals, covered for 4 hours (occluded) and washed off. Skin reactions were evaluated 1, 24, 48 and 72 hours after patch removal and, in 1 animal, at 4 and 6 days. No erythema/eschar or oedema was observed at any time point in any animal. No corrosive effects or systemic toxicity was noted. Carbonylhydridotris(triphenylphosphane)-rhodium(I) produced a primary dermal irritation index of 0 and was not irritating to the skin of rabbits under the conditions of the test.
Based on the results of this study, no classification for skin irritation is required according to EU CLP criteria (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.