Registration Dossier
Registration Dossier
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EC number: 219-330-3 | CAS number: 2416-94-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Inhalation Risk Test
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- other: Inhalation Risk Test (IRT)
Test material
- Reference substance name:
- 2,3,6-trimethylphenol
- EC Number:
- 219-330-3
- EC Name:
- 2,3,6-trimethylphenol
- Cas Number:
- 2416-94-6
- Molecular formula:
- C9H12O
- IUPAC Name:
- 2,3,6-trimethylphenol
- Details on test material:
- - Name of test material (as cited in study report): 2,3,6-Trimethyl-phenol (TMP)
No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Gassner
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE
A continuous air flow (200 l/h) was conducted through a layer of the unchanged test substance in an exsiccator.
No further data on exposure procedure. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- no further data
- Duration of exposure:
- 8 h
- Concentrations:
- 0.59 mg/l; ca. 106.08 ppm (according to the authors)
- No. of animals per sex per dose:
- 12 rats (males and females; no data on sex ratio)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating conc.
- Effect level:
- > 0.59 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: No clinical signs of toxicity were noted.
- Body weight:
- no data
- Gross pathology:
- No findings were observed.
Any other information on results incl. tables
No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that had been saturated at room temperature with the volatile parts of the compound. According to the authors, test concentration was 0.59 mg/l (ca. 106.08 ppm). Formation of dust was not observed.
Applicant's summary and conclusion
- Executive summary:
No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that had been saturated at room temperature with the volatile parts of the compound. Test concentration was 0.59 mg/l (ca. 106.08 ppm).
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