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EC number: 203-909-2 | CAS number: 111-80-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methyl non-2-ynoate
- EC Number:
- 203-909-2
- EC Name:
- Methyl non-2-ynoate
- Cas Number:
- 111-80-8
- Molecular formula:
- C10H16O2
- IUPAC Name:
- methyl non-2-ynoate
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At the start and end of the test, the pH values, dissolved oxygen concentrations and water temperature were determined in each treatment. In addition, the appearance of the test media was visually controlled and documented at the start of the test, after 24 hours and at the end of the test.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The following test concentrations of Methyl Octine Carbonate were tested: The dilutions 1:220, 1:100, 1:46, 1:22 and 1:10 of a stock solution with a loading rate of 100 mg/L. Additionally, a control (test water without test item) was tested in parallel.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The study was performed with young daphnids of the species Daphnia magna Straus. A clone of this species (originally from the Daphnia Collection of the University of Basel/Switzerland in 2015) is successfully bred in IES Ltd Laboratories under temperature and light conditions identical to those of the tests.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- The water temperature during the test was maintained at 21 °C.
- pH:
- The pH value of the test media was in the range of 7.6 to 7.9
- Dissolved oxygen:
- At the beginning and end of the test period, the dissolved oxygen concentrations in the test media and control were at least 7.9 mg/L.
- Nominal and measured concentrations:
- Nominal concentrations: 1:220, 1:100, 1:46, 1:22 and 1:10 dilutions of an equilibrated test item solution with a loading rate of 100 mg/L
Mean measured concentrations: corresponding to the above dilutions were respectively, n.a., 0.38, 0.8, 1.8 and 4.1 mg/L
n.a. = not analyzed since below the NOEC determined in this test - Details on test conditions:
- The test was performed in a temperature-controlled room with continuous monitoring of the room temperature. The test water temperature was maintained at 21 °C.
A 16-hour light to 8-hour dark cycle with a 30-minute transition period was used. Light intensity during the light period was approximately between 15 and 18 µmol m-2 s-1.
The daphnids were not fed during the test. - Reference substance (positive control):
- not required
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.38 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The test item Methyl Octine Carbonate had acute toxic effects on Daphnia magna in a static 48-hour test. The 48-hour EC50was calculated to be 1.1 mg/L with 95%-confidence limits of 0.88 and 1.5 mg/L (based on mean measured concentrations). The 48-hour NOEC of Methyl Octine Carbonate was 0.38 mg/L, since no toxic effect was observed up to and including this test concentration.
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