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Diss Factsheets
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EC number: 200-877-1 | CAS number: 75-54-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The most reliable study available was chosen as key study. Where there was more than one reliable study, the most recent study was selected. Where reliable studies were not available for the test substances, studies for an analogous substance were selected. The results of all the studies were in agreement.
Short description of key information:
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without activation in all strains tested (equivalent to OECD TG 471)
Cytogenicity in mammalian cells: read-across from analogous substance CAS 75-78-5: negative in L5178Y mouse lymphoma cells (similar to OECD TG 473)
Mutagenicity in mammalian cells: read-across from analogous substance CAS 75-78-5: negative in L5178Y mouse lymphoma cells (similar to OECD TG 476)
In vivo: read-across from analogous substance CAS 75-78-5: negative in mouse micronucleus test (US EPA guideline test, similar to OECD TG 474)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available information for the substance indicates that when tested in vitro, dichloro(methyl)silane (CAS number 75 -54 -7) did not induce mutations in bacteria. No data in mammalian cells is available for dichloro(methyl)silane. Data is, however, available for the related substance dichloro(dimethyl)silane (CAS number 75 -78 -5), which is considered a close structural analogue of dichloro(methyl)silane. Both substances have similar functional groups and hydrolyse rapidly in water to silanols . Dichloro(dimethyl)silane did not induce mutations in bacterial or mammalian cells, nor chromosome aberrations in mammalian cells. The conclusion reached from in vitro results is confirmed by the negative result obtained when dichloro(dimethyl)silane was tested in vivo in the mouse micronucleus assay. It is considered appropriate to read across the results for dichloro(dimethyl)silane to dichloro(methyl)silane. Therefore it is considered that classification for mutagenicity is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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