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EC number: 212-449-1 | CAS number: 818-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 January 2015 to 15 January 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The only suitable analytical method that could be used was ICP-AES. ICP-AES is not a substance-specific form of analysis as it measures the total tin content (which will include any soluble impurities). However, it is considered that since the % of impurities in the sample tested is very low the value obtained is considered to be representative.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7860 (Water Solubility Generator Column Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 2.55 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: 2.55 ± 0.16 mg a.i./L (CV = 6.5 %, N = 11).The measured pH of reagent water and an aqueous sample was 6.5 and 4.4, respectively.
- Details on results:
- The matrix blank sample did not show any spectral interferences and background levels were significantly below the low-level calibration standard.
The temperature of the water bath remained constant at 20.0 ± 0.1 °C throughout the experiment.
Under the instrumental conditions presented, the mean measured reagent water solubility of the test material at 20 °C was 2.39 ± 0.084 mg a.i./L (CV = 3.5 %, N = 5) at a flow rate of approximately 1.0 mL/min and was 2.67 ± 0.071 mg a.i./L (CV = 2.7 %, N = 6) at a flow rate of approximately 0.5 mL/min (Table 1).
The mean test material concentration for the approximately 1.0 and 0.5 mL/min flow rate settings differed by 11 %, which was well within the ± 30 % test criterion. The overall mean measured water solubility at 20 °C was 2.55 ± 0.16 mg a.i./L (CV = 6.5 %, N = 11).
The pH was measured for an aqueous sample collected at a flow rate of 1.0 mL/min. The measured pH of reagent water and an aqueous sample was 6.5 and 4.4, respectively. - Conclusions:
- Under the conditions of this study the water solubility of the test material in reagent water at 20 °C was determined to be 2.55 ± 0.16 mg a.i./L.
- Executive summary:
The water solubility of the test material was determined in a study conducted in accordance with the standardised guidelines OECD 105, US EPA OPPTS 830.7840 and OPPTS 830.7860 under GLP conditions.
The test was performed using reagent-grade water and the column elution method as modified by use of a generator column apparatus. The test was carried out using flow rates of 1.0 and 0.5 mL/minute. The test was terminated when the mean measured concentrations of the test material at the two flow rates were determined to be within 30 % of each other.
The matrix blank sample did not show any spectral interferences and background levels were significantly below the low-level calibration standard. The temperature of the water bath remained constant at 20.0 ± 0.1 °C throughout the experiment.
Under the instrumental conditions presented, the mean measured reagent water solubility of the test material at 20 °C was 2.39 ± 0.084 mg a.i./L (CV = 3.5 %, N = 5) at a flow rate of approximately 1.0 mL/min and was 2.67 ± 0.071 mg a.i./L (CV = 2.7 %, N = 6) at a flow rate of approximately 0.5 mL/min. The measured pH of reagent water and an aqueous sample was 6.5 and 4.4, respectively.
The mean test material concentration for the approximately 1.0 and 0.5 mL/min flow rate settings differed by 11 %, which was well within the ± 30 % test criterion.
Under the conditions of this study, the overall mean measured water solubility at 20 °C was 2.55 ± 0.16 mg a.i./L (CV = 6.5 %, N = 11).
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted to GLP in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results. Both runs were performed at the same flow rate. OECD Guideline 105 specifies that the second run should be performed at ½ the flow rate. The analytical method used (ICP) was not compound-specific. The solubility of the test substance was based on measurement of total tin in the samples. Measurement of total tin potentially includes any contribution(s) from more water-soluble impurities or hydrolysis products. DBTO is a hydrolysis product of the dibutyltins and is not subject to hydrolysis itself. In water, DBTO will precipitate as a stable oligomeric acid.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Principles of method if other than guideline:
- No further information required.
- GLP compliance:
- not specified
- Type of method:
- column elution method
- Water solubility:
- 4 mg/L
- Temp.:
- 20 °C
- pH:
- 6.1
- Details on results:
- pH Concentration: 4 mg/l at 20 °C. The standard deviation is 0.15 mg/L. The repeatability of the runs is less than 20% and fulfils the required condition for repeatability <30% for the elution method.
- Conclusions:
- Based on the two independent runs, the water solubility of dibutyltin oxide was 4.0 ± 0.15 mg/L at 20 ºC.
- Executive summary:
In accordance with OECD Guideline No. 105, the column elution method was used for the determination of the water solubility. Based on the two independent runs, the water solubility of dibutyltin oxide was 4.0 ± 0.15 mg/L .at 20 ºC.
Referenceopen allclose all
Table 1: Measured Concentration of the Test Material in Aqueous Samples Collected at 20.0 °C
Sample Number |
Measured Flow rate (mL/min) |
Calculated Test Material Concentration (mg/L) |
Mean Calculated Concentration (mg/L) |
1 |
1.0 |
2.27 |
2.39 ± 0.084 CV = 3.5 % |
3 |
2.39 |
||
4 |
2.38 |
||
5 |
2.42 |
||
6 |
2.50 |
||
7 |
0.5 |
2.67 |
2.67 ± 0.071 CV = 2.7 % |
8 |
2.70 |
||
9 |
2.70 |
||
10 |
2.60 |
||
11 |
2.78 |
||
12 |
2.59 |
CV = Coefficient of Variation
Overall: Mean = 2.55 ± 0.16 mg/L, CV = 6.5 % and % difference = 11 %
Description of key information
The overall mean measured water solubility at 20 °C was 2.55 ± 0.16 mg a.i./L (CV = 6.5 %, N = 11).
Key value for chemical safety assessment
- Water solubility:
- 2.55 mg/L
- at the temperature of:
- 20 °C
Additional information
In the key study (Van Hoven et al., 2015), the water solubility of the test material was determined in a study conducted in accordance with the standardised guidelines OECD 105, US EPA OPPTS 830.7840 and OPPTS 830.7860 under GLP conditions. it was awarded a reliability score of 1 in accordance with the principles set forth by Klimisch et al. (1997).
The only suitable analytical method that could be used was ICP-AES. ICP-AES is not a substance-specific form of analysis as it measures the total tin content (which will include any soluble impurities). However, it is considered that as the registered material is the main constituent of the test material, the value obtained is considered to be representative.
The test was performed using reagent-grade water and the column elution method as modified by use of a generator column apparatus. The test was carried out using flow rates of 1.0 and 0.5 mL/minute. The test was terminated when the mean measured concentrations of the test material at the two flow rates were determined to be within 30 % of each other.
The matrix blank sample did not show any spectral interferences and background levels were significantly below the low-level calibration standard. The temperature of the water bath remained constant at 20.0 ± 0.1 °C throughout the experiment.
Under the instrumental conditions presented, the mean measured reagent water solubility of the test material at 20 °C was 2.39 ± 0.084 mg a.i./L (CV = 3.5 %, N = 5) at a flow rate of approximately 1.0 mL/min and was 2.67 ± 0.071 mg a.i./L (CV = 2.7 %, N = 6) at a flow rate of approximately 0.5 mL/min. The measured pH of reagent water and an aqueous sample was 6.5 and 4.4, respectively.
The mean test material concentration for the approximately 1.0 and 0.5 mL/min flow rate settings differed by 11 %, which was well within the ± 30 % test criterion.
Under the conditions of this study, the overall mean measured water solubility at 20 °C was 2.55 ± 0.16 mg a.i./L (CV = 6.5 %, N = 11).
This was selected as the key study as the most up to date and sensitive analytical methodology was used.
In the supporting study (Schering, 1989), the water solubility of dibutyltin oxide was determined to be 4.0 ± 0.15 mg/L at 20 ºC.
The study was conducted to recognised guidelines and according to the criteria of Klimisch et al. (1997) a reliability rating of 2 was assigned to this study.
Both runs were performed at the same flow rate. OECD Guideline 105 specifies that the second run should be performed at ½ the flow rate. The analytical method used (ICP) was not compound-specific. The solubility of the test substance was based on measurement of total tin in the samples. Measurement of total tin potentially includes any contribution(s) from more water-soluble impurities or hydrolysis products. DBTO is a hydrolysis product of the dibutyltins and is not subject to hydrolysis itself. In water, DBTO will precipitate as a stable oligomeric acid.
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