Registration Dossier

Physical & Chemical properties

Boiling point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Well documented study performed according to OECD 103 guideline and EU method A.2, under GLP and without deviation
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
2015-03-05
Type of method:
differential scanning calorimetry
Boiling pt.:
ca. 155.5 °C
Atm. press.:
ca. 1 018.3 hPa
Decomposition:
no
Remarks on result:
other: First determination
Boiling pt.:
ca. 155.2 °C
Atm. press.:
ca. 1 025.5 hPa
Decomposition:
no
Remarks on result:
other: Second determination
Key result
Boiling pt.:
ca. 155 °C
Atm. press.:
ca. 101.3 kPa
Remarks on result:
other: Corrected value with the Sydney Young equation

Pre-study:

Peaks assigned to the boiling of the substance were observed and measurement was stopped at 550°C (Figure 1).Temperatures corresponding to these peaks were used to create the following temperature program:

Temperature program:

Step

Initial temperature (°C)

Final Temperature (°C)

Heating rate (°C/min)

Duration (min)

Furnace atmosphere

Rate* (mL/min)

Liquid nitrogen cooling

1

20

-120

10

14

He

60

YES

2

-120

-120

0

5

He

60

NO

3

-120

210

10

40

He

60

NO

*Gas injection rate in the furnace. 

 

First Determination:

 

Mass taken: 11.01 mg

 

Results

Initial boiling point is observed at 155.5°C (onset temperature of the first peak) and a corresponding mass loss is observed on the TG curve, showing that all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

Atmospheric pressure: 1018.3 hPa

Second Determination:

 

Mass taken: 13.32 mg

 

Results :

Initial boiling point is observed at 155.2°C(onset temperature of the first peak) and a corresponding mass loss is observed on the TG curve, showing that all the substance was evaporated at the end of the study. 

The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

Atmospheric pressure: 1025.5 hPa

Conclusions:
According to OECD 103 guideline and EU method A.2, the initial boiling point of substance (-)-alpha-pinene was determined as 155.0°C at 101.3 kPa after correction using the Sydney Young equation.
Executive summary:

A study was performed to determine the boiling point of test item (-)-alpha-pinene. The method used was Differential Scanning Calorimetry (DSC) and the test was according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103, "Boiling Point" (1995)

In this method, two crucibles were put in the apparatus furnace under inert atmosphere (helium) at atmospheric pressure. One crucible contained the test item, the other was empty and considered as the reference. A specific temperature program was applied. Heat flow differences between the two crucibles and mass variation were recorded on a thermogram.

Two trials were conducted and corresponding thermograms were obtained, giving us the following results:

Trial

Initial boiling point

Ambient pressure

1

155.5°C

1018.3 hPa

2

155.2°C

1025.5 hPa

This study respects validity criteria (the difference temperature between the two determinations is less than 1°C), therefore it is considered valid.

After correction using the Sydney Young equation, the initial boiling point of the substance was determined as 155.0°C at 101.3 kPa.

Description of key information

The initial boiling point of substance (-)-alpha-pinene was determined as 155.0°C at 101.3 kPa.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
155 °C

Additional information

Key study conducted according to the OECD 103 Guideline and the EU A.2 method, under GLP without deviation and with certificate of analysis included. Therefore, a reliability of 1 is assigned and the result of this key study is proposed as the end point value.

This result is supported by consistent experimental data obtained with alpha-pinene multiconstituent.