Registration Dossier
Registration Dossier
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EC number: 211-119-4 | CAS number: 629-96-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-01-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Test procedure in accordance with national standard methods (ASTM) without GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM E 1147
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 8.3
- Remarks on result:
- other: The temperature of the measurement is not reported.
- Conclusions:
- A log Kow value of 8.3 was determined for the substance using a relevant test method. The result is considered to be reliable.
- Executive summary:
Icosan-1-ol was determined according ASTM E 1147 . The partition coefficient was determined to be log Pow 8.3.
Reference
Measurement
Log Kow: 8.3
Description of key information
The log octanol-water partition coefficient of a commercial sample of icosan-1-ol is 8.3 (by HPLC method). A log Kow value of 7.75 would be predicted for the pure linear alcohol based on category trends.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 8.3
Additional information
A log n-octanol/water partition coefficient value of 8.3 was determined for icosan-1-ol using an HPLC method in accordance with ASTM E 1147. The result is considered to be reliable.
It is supported by a value of 7.75 determined by HPLC for a pure sample and reported in published literature, which is consistent with the category trends.
The published value is used in exposure modelling.
Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:
As chain length increases, the free energy required for a molecule to dissolve becomes less favourable for larger molecules. The octanol-water partition coefficient increases with molecular weight because each additional -CH2- group makes the octanol phase more preferred over water in terms of relative solvation energy.
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