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EC number: 242-555-3 | CAS number: 18755-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Valid studies for acute oral toxicity according OECD 401 and acute inhalation toxicity according OECD 403 are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Five male and five female Wistar rats (176-188 g) received a single dose of 2000 mg/kg bw of dimethyl propylphophonate per gavage. The animals were observed for mortality, body weights and clinical signs through day 14. A gross necropsy was performed on animals sacrificed at the end of the 14 days observation period.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female animals/dose
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Executive summary:
Five male and five female Wistar rats (176-188 g) received a single dose of 2000 mg/kg bw of dimethyl propylphosphonate
per gavage. The animals were observed for mortality, body weights and clinical signs through day 14. A gross necropsy was performed on animals sacrificed at the end of the 14 days observation period.A dose of 2000 mg/kg bw caused a staggared gait, sedation, paresis of the hind limbs, ruffle fur, chromodacryorrhoe, haggard flanks, and crouch position. One female rat died 3 days after the application of 2000 mg/kg bw of dimethyl propylphosphonate.
The LD50 is > 2000 mg/kg bw (male and female rats) and was not exactly determined.
Reference
A dose of 2000 mg/kg bw caused a staggared gait, sedation, paresis of the hind limbs, ruffle fur, chromodacryorrhoe, haggard flanks, and crouch position.
Body weight gain was not influenced by male rats. The surviving female rats revealed a weight loss during the first observation week and one animal of both weeks.
One female rat died 3 days after the application of 2000 mg/kg bw of dimethyl propylphosphonate. The bladder was filled with blood and the intestines were filled with faces of hard consiscence.
One female rat killed after 14 days revealed a reddened intestine mucosa. All other animals were without finding at the gross necropsy.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 001 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail und are sufficient for evaluation
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- One group of 3 male and 3 female Wistar rats was nose-only exposed to dimethyl propylphosphonate (DMPP) at an actual aerosol concentration of 5788 mg/m³ for 4 hours. The aerosol was generated neat without any vehicle. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5788 mg/m³
- No. of animals per sex per dose:
- control group: 5 male and 5 female rats
test group: 3 male and 3 female rats - Control animals:
- yes
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 788 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Executive summary:
One group of 3 male and 3 female wistar rats was nose-only exposed to dimethyl propylphosphonate (DMPP) at an actual aerosol concentration of 5788 mg/m³ for 4 hours. The aerosol was generated neat without any vehicle. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed.
The maximum tested concentration was tolerated without mortality.
The following clinical signs were observed: bradypnea, labored breathing patterns, piloerection, motility reduced, atony, high-legged gait; lurching, hypothermia, decreased reflexes, and transient decrease in body weights. The lead pathodiagnostic effects were
suggestive of mild and rapidly reversible portal of entry-related effects (irregular and labored breathing patterns which were observed up to the first postexposure day). Gross necropsy was unobtrusive.
The acute LC50 (aerosol) of dimethyl propylphosphonate is > 5788 mg/m³ in male and female rats.
Reference
The maximum tested concentration was tolerated without mortality.
The following clinical signs were observed: bradypnea, labored breathing patterns, piloerection, motility reduced, atony, high-legged gait; lurching, hypothermia, decreased reflexes, and transient decrease in body weights. The lead pathodiagnostic effects were
suggestive of mild and rapidly reversible portal of entry-related effects (irregular and labored breathing patterns which were observed up to the first postexposure day).
Gross necropsy was unobtrusive.
The respirability of the aerosol was adequate to achieve the objective of study, i.e. the average mass median aerodynamic diameter (MMAD) was 4.6 µm, the average geometric standard deviation (GSD) was 1.8. Measures were made to maximize the respirability of aerosol; however, at the expense of the actual concentration. Due to the marginal evidence of mild upper respiratory tract irritation, further exposure at lower but more respirable aerosol does not seem to be justified scientifically nor on animal welfare reasons.
In summary, the aerosolized test substance (liquid aerosol) proved to have a low acute inhalation toxicity in rats.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 5 788 mg/m³ air
- Quality of whole database:
- The materials/methods and results are described in detail und are sufficient for evaluation
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the acute oral toxicity study a dose of 2000 mg/kg bw caused a staggered gait, sedation, paresis of the hind limbs, ruffle fur, chromodacryorrhoe, haggard flanks, and crouch position. One female rat died 3 days after the application of 2000 mg/kg bw of the test substance. The LD50 is > 2000 mg/kg bw (male and female rats) and was not exactly determined.
In the acute inhalation toxicity study male and female Wistar rats were nose-only exposed to dimethyl propylphosphonate (DMPP) at an actual concentration of 5788 mg/m³ for 4 hours. The maximum tested concentration (5788 mg/m³) was tolerated without mortality.
The following clinical signs were observed: bradypnea, labored breathing patterns, piloerection, motility reduced, atony, high-legged gait; lurching, hypothermia, decreased reflexes, and transient decrease in body weights. The lead pathodiagnostic effects were suggestive of mild and rapidly reversible portal of entry-related effects (irregular and labored breathing patterns which were observed up to the first postexposure day). Gross necropsy was unobtrusive.
The acute LC50 (aerosol) of dimethyl propylphosphonate is > 5788 mg/m³ in male and female rats.
Justification for selection of acute toxicity – oral endpoint
only available study
Justification for selection of acute toxicity – inhalation endpoint
only available study
Justification for classification or non-classification
Due to the results of the acute oral toxicity study (LD50 > 2000 mg/kg bw) and the acute inhalation toxicity study (LC50 > 5788 mg/m³) a classification is not justified.
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