Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

One study was carried out on the mixture of isomers (CERI, 2000) and two other studies were conducted on the isomers 1 ,3-DIPB and 1,4-DIPB respectively (Eastman, 1984, 1986).

The study performed on the mixture used dispersant, and the estimated toxicity values were found to be higher than the water solubility determined by CERI: 48h EC50 = 0.392 mg/L (95% C.L.: 0.624 -0.843 mg/L; measured concentration).

The meta isomer was tested for acute toxicity towards Daphnia magna for 48H in a methodology equivalent to OECD 202 guideline and following GLP. The test was conducted using a flow-through, recirculating elutriation system designed to expose the organisms to an exposure concentration at or near the solubility of the test substance. Separate tests indicated that the test substance exhibited low solubility and high volatility in water. Therefore, the measured concentration of m-DIPB (0.93 mg/L) was the result of the low solubility and high volatility of the test substance, but reflected the most effective experimental flow-through design to maximize the exposure concentration. The toxicity test on p-DIPB was conducted in a similar manner. Therefore, these tests were conducted using the most effective experimental designs. The exposed daphnia exhibited behavior comparable to controls The conclusion was that the meta and para isomers arenot toxic to daphnia at solubility limit.

Key value for chemical safety assessment

Additional information

EC50-48H > 0.93 mg/L