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Diss Factsheets
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EC number: 613-099-6 | CAS number: 62889-66-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Batch No.: Batch 704/tank 328
- Storage condition of test material: refrigerator
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr . K . Thomae GmbH, 7950 Biberach, Germany
- Weight at study initiation: (200 g - 300 g ; ± 20% of the mean weight)
- Housing: Single housing in Stainless steel wire mesh cages, type DK-III (Becker & Co, Castrop- Rauxel, Germany) .
- Diet: KLIBA-Labordiaet 343, Klingentalmuehle AG, 4303 Kaiseraugst, Switzerland, ad libitum
- Water: tap water ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Clipping of the fur: at least 15 hours before the beginning of the study
- Area of exposure: dorsal and dorsolateral parts of the trunk; 50 cm2
- Type of wrap if used: the bandage consist of four layers absorbent gauze
REMOVAL OF TEST SUBSTANCE
- Washing: warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 2000 mg/kg bw - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Recording of signs and symptoms several times on the day of administration, thereafter at least once each workday for the individual animals
- Freuqency of weighing: shortly before the study and at the last day
- Necropsy of survivors performed: yes
- Other examinations performed: Scoring of skin findings: Individual readings 30 - 60 minutes after removal of the semiocclusive dressing (day 1),
weekly thereafter and at the end of the study (last day of the observation period)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality observed
- Clinical signs:
- No abnormalities
- Body weight:
- body weight gain
- Gross pathology:
- No pathological findings
- Other findings:
- Local effects (see table 1):
In the male animals moderate to severe erythema and in single cases additionally slight edema, incrustation and scaling were seen. 14 days after application in all male animals signs of reversibility were observed.
In the female animals well-defined erythema, scaling and in some cases slight edema were seen. Erythema could still be observed 14 days after application.
Any other information on results incl. tables
Table 1: Number of treated male and female animals with Edema / erythema and duration of adverse effects.
males | females | |||
Number of animals | Reversibility | Number of animals | Reversibility | |
moderate to severe erythema | 4 | D1 | ||
well-defined erythema | 5 | D1-D7 | 5 | D1-D14 |
very slight erythema | 2 | D7-D14 | 3 | D14 |
slight edema | 3 | D1 | 2 | D1 |
very slight edema | 1 | D1 | 3 | D1 |
scaling | 5 | D7-D14 | 5 | D7-D14 |
incrustation | 4 | D7-D14 | 1 | D7 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.