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Diss Factsheets
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EC number: 203-931-2 | CAS number: 112-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Rapid absorption of free fatty acids from the gut following ingestion of either natural or synthetic fats and oils or of free fatty acid or its salt. Rapid and complete metabolism in the liver, with no other metabolites than carbon dioxide and water. No bioaccumulation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
Additional information
Pelargonic is a naturally occurring fatty acid (see EFSA, 2021). Like all other naturally occurring fatty acids, pelargonic acid is utilized as food substrate for virtually all life forms including bacteria, fungi, algae, plants, animals and human beings (Zschintzsch, 2003). Fatty acids are required for the organism's energy supply and biosynthesis of a variety of biomolecules including adipose and membrane lipids.
In mammals and humans, absorption takes place through the cell membranes of the intestinal brush border cells of the jejunum, regardless of whether the fatty acid moiety is ingested as free fatty acid, as a salt or as a component of lipids. Short and intermediate chain fatty acids, like pelargonic acid, are absorbed directly and rapidly from the intestinal lumen into the portal circulation where they are bound to serum proteins and are transported to the liver and other tissues (Zschintzsch, 2003).
ß-oxidation in the mitochondria is the main metabolic pathway (Zschintzsch, 2003; Cragg, 2001; WHO, 1998). Even-numbered fatty acids are degraded via ß-oxidation to CO2and acetyl-CoA, under the release of biochemical energy. Odd-numbered fatty acids like pelargonic acid are similarly decomposed to CO2 and propionyl-CoA. The latter undergoes further degradation to succinyl-CoA resp. acetyl-CoA. These compounds are oxidized via the citric acid cycle to CO2 and water. No other ultimate excretion products than CO2 and water will be formed. Thus, pelargonic acid or metabolites thereof are unlikely to accumulate (Zschintzsch, 2003).
EFSA (European Food Safety Authority), Alvarez F, et al., 2021. Conclusion on the peer review of the pesticide risk assessment of the active substance pelargonic acid (nonanoic acid). EFSA Journal 2021;19 (8):6813, 28 pp. https://doi.org/10.2903/j.efsa.2021.6813
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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