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EC number: 289-296-2 | CAS number: 87061-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 July 1984 to 24 October 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccumulation test of chemical substances in fish and sellfish" described in "Kanpogyou, No.5", "Yakuhatsu, No.615" and "49 Kikyoku, No.392
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Appearance under ambient temperature; transparent clear liquid
Solubility;
Water: more than 500 mg/L (by TOC meter)
n-Hexane: more than 1000 mg/L
Chloroform: more than 1000 mg/L
Benzene: more than 1000 mg/L
Acetonitrile: more than 1000 mg/L - Radiolabelling:
- no
- Details on sampling:
- (1) Test water;
The test substance in the test water was analysed twice every week, 16 times in total for both concentration 1 and 2 area during exposure period using one sample each time.
(2) Test fish;
The test substance in the test fish was analysed 2,4,6 and 8 week, 4 times in total, after the initiation of exposure for both concentration 1 and 2 area, using two fish samples each time. - Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- (1) Test material concentration of test water
The test material concentration in the test aquarium was decided as follows
Concentration 1 area: 0.5 mg/L (ppm)
Concentration 2 area; 0.05 mg/L (ppm)
(2) Preparation method of stock solution
The test substance (1.5 g) and 5 times amount of HCO-40 (polyoxyethylene hardened castor oil derivative; NIKKO CHEMICALS CO., LTD.) were dissolved in acetone and mixed. Then, the acetone was distilled away and added deionized water. The mixture was stirred to obtain suspended stable solution of 5000 mg/L concentration. This solution was diluted with deionised water to obtain each stock solution of 25 L for concentration 1 area (50 mg/L) and concentration 2 area (5 mg/L). The each stock solutions were prepared twice a week during exposure period. - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST FISH;
Common name: Common carp
Species: Carp (Cyprinus carpio)
Source: Kitamura fish farm (Yatsushiro-city, Kumamoto)
Lot. No.: TFC840717
Medical bath: The medical bath was performed using tetracycline hydrochloride solution (10 mg/L) under static water conditions during 24-hours.
Acclimatisation period: 14 days, 25°C.
Standard size of used fish*:
Mean body weight; 22.4 g
Mean length; 9.7 cm
Mean content of lipid; 4.2%
* Measured value of representative sample from same acclimatisation lot. - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
- Hardness:
- no description
- Test temperature:
- Breeding temperature: 25 ± 2°C
- pH:
- no description
- Dissolved oxygen:
- Dissolved oxygen concentration in test aquarium:
Concentration 1 area; 5.7 – 7.3 mg/L
Concentration 2 area; 6.2 – 7.5 mg/L - TOC:
- no discription
- Salinity:
- no data due to freashwater study
- Details on test conditions:
- TEST SYSTEM;
(1) Breeding equipment: Environmental control equipment with a flow-through water system
(2) Breeding bath: 100 L glass aquarium
(3) Flow rate: 582 L/day
(stock solution : dilution water = 4 mL/minute : 400 mL/minute)
(4) Number of test fish used: 20 fish each breeding aquarium ( at the initiation of exposure)
(5) Breeding period: 8 weeks
(6) Breeding temperature: 25 ± 2°C
(7) Feeding: An amount of corresponding to about 2% of the test fish bodyweight was fed twice daily in halves.
RATIONAL OF THE TEST MATERIAL CONCENTRATION FOR DEFINITIVE TEST;
Based on the preliminary test result for 48-hr LC50, the test material concentrations for definitive test were determined as follows;
Concentration 1 area: 0.5 mg/L
Concentration 2 area: 0.05 mg/L
PRELIMINARY TEST;
(1) Test method: The preliminary test was performed according to the method of “Acute Toxicity Test in Fish” described in Factory Effluent Test Method provided in JIS K 0102 using HCO-40 as dispersing agent.
(2) Species: Killifish (Oryzia latipes)
(3) During exposure: 48 hours
(4) Test result: 48-hr LC50 of test substance; 48.5 mg/L
(5) Dilution water: well water - Nominal and measured concentrations:
- The nominal test material concentrations and the mean measured test material concentrations of test water were shown in Table.2.
- Reference substance (positive control):
- no
- Lipid content:
- 4.2 %
- Time point:
- start of exposure
- Remarks on result:
- other: The values of mean body weight, mean length and mean content of lipid for used fish were shown measured values of reperasentative samplefrom same acclimatisation lot.
- Conc. / dose:
- 0.5 mg/L
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- >= 2.1 - <= 3.3 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks on result:
- other: no data on pH provided
- Conc. / dose:
- 0.05 mg/L
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- >= 2.1 - <= 3.9 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks on result:
- other: no data on pH provided
- Details on kinetic parameters:
- no description
- Metabolites:
- no description
- Results with reference substance (positive control):
- no use of reference substance
- Details on results:
- Abnormalities of test fish; No macroscopic abnormalities of test fish were observed during test period.
Mean test material concentration of test water;
As the mean test material concentration of test water, the measured values more than 90% of nominal concentration shown in Table 2 were maintained during exposure period.
Bioaccumulation factor; Table 1 - Validity criteria fulfilled:
- not specified
- Conclusions:
- The bioconcentration factor of the test material was determined to be between 2.1 and 3.9 over a period of 8 weeks.
- Executive summary:
The bioaccumulation potential of the test material was determined in a study conducted to the method "Bioaccumulation test of chemical substances in fish and shellfish" described in "Kanpogyou, No.5", "Yakuhatsu, No.615" and "49 Kikyoku, No.392 under conditions of Good Laboratory Practice.
The bioconcentration factor of the test material was determined over a period of 8 weeks to be between 2.1 and 3.3 when the test material was present in nominal concentrations of 0.5 mg/L and between 2.1 and 3.9 when fish were exposed to concentrations of 0.05 mg/L.
Reference
Table 1: Bioaccumulation factor
Table 2: Test material concentration of test water (nominal and measure value)
Description of key information
The bioconcentration factor of the test material was determined to be between 2.1 and 3.9 over a period of 8 weeks.
Key value for chemical safety assessment
Additional information
The bioaccumulation potential of the test material was determined in a study conducted to the method "Bioaccumulation test of chemical substances in fish and shellfish" described in "Kanpogyou, No.5", "Yakuhatsu, No.615" and "49 Kikyoku, No.392 under conditions of Good Laboratory Practice. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The bioconcentration factor of the test material was determined over a period of 8 weeks to be between 2.1 and 3.3 when the test material was present in nominal concentrations of 0.5mg/L and between 2.1 and 3.9 when fish were exposed to concentrations of 0.05 mg/L.
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