Registration Dossier
Registration Dossier
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EC number: 202-216-2 | CAS number: 93-08-3
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5 yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constant. Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.
Additional information
Hydrolysis:
Data available for the test chemical has been reviewed from authoritative database (HSDB, 2018) to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
In first weight of evidence study the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.2 × 10-2 L/mol-sec with a corresponding half lives of 5.5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
In another study the base catalyzed second order hydrolysis rate constant and half life of hydrolysis of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.0 × 10-2L/mol-sec with a corresponding half lives of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5 yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constant . Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.
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