Registration Dossier
Registration Dossier
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EC number: 210-545-8 | CAS number: 618-36-0
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
Acutely harmful to fish.
The acute toxicity of DL-alpha-methylbenzylamine was studied according to OECD 203 under GLP using zebrafish (Danio rerio) as test species. The test item concentrations were analytically verified and were demonstrated to be stable over the exposure period. The 96 -h LC50 was 25.6 mg/L (nominal; BASF SE, 2012; project no. 17F0728/11X318).
Based on this test result, the test substance is acutely harmful to fish.
Long-term toxicity to fish:
Not required.
Short-term toxicity to aquatic invertebrates:
Acutely harmful to aquatic invertebrates.
A 48 -h EC50 of 23.3 mg/L was determined in a study testing the toxicity of DL-alpha-methylbenzylamine toDaphnia magnaconducted according to Dir. 79/831/EEC, Annex V, Part C. (BASF AG, 1996). The effect of the substance on the mobility ofD. magnais probably in part due to pH changes caused by the substance. In a parallel test with a neutralised sample of the two highest concentrations (50 and 100 mg/L) the toxicity of the test item was reduced as after 48 h the immobilisation was ca. 50% compared to 100% in the not-neutralised sample fo 50 mg/L. Moreover, the effects were delayed in time as 80% of the daphnids were immobilised after 48 h in the neutralised 100 mg/L sample while in the not-neutralised sample all daphnids were immobilised already after 3 h. The test item concentrations were analytically verified.
Long-term toxicity to aquatic invertebrates:
Not required
Toxicity to aquatic algae and plants:
The toxicity of DL-alpha-methylbenzylamine was studied in a growth inhibition test according to OECD 201 under GLP with Pseudokirchneriella subcapitata as test species (BASF SE, 2012; project no.60E0728/11X317). The test concentrations were analytically verified and proved to be stable over the exposure period. The 72 -h ErC50 was determined to be 31.7 mg/L (95% CL: 28.9 to 34.8 mg/L). The 72 -h ErC10 was determined to be 9.2 mg/L (95% CL: 7.3 to 10.9 mg/L). It can be concluded that the substance is acutely harmful to aquatic algae.
Toxicity to microorganisms:
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
The toxicity is assessed via a read-across approach to short-term respiration inhibition tests (OECD 209) with two structurally similar substances (D-alpha-methylbenzylamine, CAS 3886 -69 -9; L-alpha-methylbenzylamine, CAS 2627 -86 -3). The lowest 30 -min EC20 of both tests was ca. 550 mg/L (BASF AG, 1998; report no. 98/320/08/1).
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