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EC number: 292-947-3 | CAS number: 91031-45-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects to aquatic algae up to the limit of water solubility (< 0.05 mg/L; EU Method C.3, DIN 38412-9).
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity to aquatic algae and cyanobacteria of fatty acids, C16-18, 1,2-ethanediylbis(oxy-2,1-ethanediyl) esters (3EO) (CAS 91031-45-7) are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the three structurally most similar analogue substances butylene glycol dicaprylate / dicaprate (CAS 853947-59-8), fatty acids, C16-18, esters with ethylene glycol (CAS 91031-31-1) and decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) was conducted. This read-across is justified in detail within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the analogue justification in IUCLID section 13 and the overall endpoint summary in IUCLID section 6. 1, all reliable data from the analogue substances support the hazard assessment by showing a consistent pattern of results.
The first study with butylene glycol dicaprylate / dicaprate was performed as a limit test according to EU Method C.3 using the freshwater algae Scenedesmus subspicatus (Scholz, 1997). A test substance concentration of 1000 mg/L (nominal) and 3 mg/L (measured, based on TOC content) respectively, did not result in any effects on the growth rate and biomass after 72 h resulting in an EL10/50 > 3 mg/L (measured, initial). The recovery rate in the stability test was > 80% and the concentration after 48 and 72 h did not differ more than 20%. Therefore, the test substance was bioavailable throughout the test.
The second study with the read-across substance fatty acids, C16-18, esters with ethylene glycol was performed according to the DIN 38412-9 under GLP conditions (Stelter, 1994). The green algae Scenedesmus subspicatus was exposed to nominal concentrations of 10 and 100 mg/L without a further filtration step. No inhibition of growth of S. subspicatus up to the limit of water solubility was observed resulting in an EC50 > 100 mg/L. An EC10 of 34 mg/L was determined since growth stimulation was observed in both concentrations used in this study.
The third study with the read-across substance decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) was performed according to the EU Method C.3 under GLP conditions (Scholz, 1995). The green algae Scenedesmus subspicatus was exposed to a Water Accommodated Fraction (WAF) of nominal 5.3 mg/L and subsequent dilutions for 72 h. No effects on the growth rate of S. subspicatus up to the limit of water solubility were observed resulting in an ELr50 > 5.3 mg/L and a NOELR of ≥ 5.3 mg/L.
Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by showing consistent results, it can be concluded that fatty acids, C16-18, 1,2-ethanediylbis(oxy-2,1-ethanediyl) esters (3EO) will not exhibit effects to aquatic algae up to the limit of water solubility.
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