Registration Dossier
Registration Dossier
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EC number: 418-370-0 | CAS number: 143925-92-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The test item is a product by process with the two main lipophilic components named hydroxylamine and Armeen 2HT (secondary amine) and has a low water solubility and a partition coefficient larger than 10. The two main components are assumed to be absorbed from the gastrointestinal tract to some extent and distributed through the lymphatic system, eventually entering the systemic circulation. This prediction was confirmed by the outcome of the repeat-dose toxicity studies which identified the mesenteric lymph nodes, liver, kidney and skeletal muscle as target organs at doses equal and larger than 200 mg/kg/day. The findings were not or at least partially reversible after cessation of treatment. It is more convincing to assume that the recovery period was too short for a full reversibility of the effects rather than assuming a bioaccumulating potential of the test substance.
The metabolic fate of the test article, especially the hydroxylamine component, is suggested to lead to nitrone formation, followed by oxidation to the respective oxime, which then result in the aldehyde and hydroxylamine by oxidation/hydrolysis. This could be proven experimentally in an abiotic hydrolysis test simulating artificial gastric fluid (acidic conditions; for reference see under hydrolysis).
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