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EC number: 201-964-7 | CAS number: 90-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The purity of the test substance, the vehicle, the strain and the sex of the rabbits were not reported. The protocol appeared to be similar from the standard method. The GLP were not mentioned but the study was performed before the GLP standard was established.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Kirwin C.J., Galvin J.B.
- Year:
- 1 982
- Bibliographic source:
- Journal Patty's Industrial Hygiene and Toxicology. 4th ed. New York: John Wiley Sons, 448-449, 481-485. Ethers: chapter 8.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials
- Author:
- Opdyke DL, Letizia C.
- Year:
- 1 982
- Bibliographic source:
- Food Chem Toxicol, 20, 697-701.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute dermal toxicity
- GLP compliance:
- no
- Test type:
- other: dermal toxicity
- Limit test:
- no
Test material
- Reference substance name:
- Guaiacol
- EC Number:
- 201-964-7
- EC Name:
- Guaiacol
- Cas Number:
- 90-05-1
- Molecular formula:
- C7H8O2
- IUPAC Name:
- Phenol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- ADMINISTRATION / EXPOSURE: on abraded or intact skin
No more details - Duration of exposure:
- no data
- Doses:
- 2500, 3530, 5000 mg/kg bw
- No. of animals per sex per dose:
- 4 animals per dose, sex unspecified.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross examination - Statistics:
- Harris method
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 600 mg/kg bw
- 95% CL:
- > 3 800 - < 5 400
- Remarks on result:
- other: In the same study, dermal irritation was evaluated.
- Mortality:
- 3/4 animals at 5000 mg/kg bw
- Clinical signs:
- other: at 2500 and 3530 mg/kg bw slight diarrhea was noted. At 5000 mg/kg bw, 3/4 rabbits died on days 1 and 8 and slight diarrhea, anorexia, lethargy, pilorection, emaciation, yellowish discharge at nose, ataxia and flaccid muscle tone were observed.
- Gross pathology:
- Necropsy revealed no abnormalities in all animals treated with 3530 mg/kg bw and in 2/4 rabbits treated with 2500 mg/kg bw.
At 2500 mg/kg bw dose level, red areas in intestines were observed in 2/4 animals; dark liver in 2/4 animals; large spleen in 1/4 animals; skin
hard/thick in 1/4 animals.
At 5000 mg/kg dose level, necropsy revealed red exudate in the nose/mouth in 2/4 rabbits; brown anogenital exudate in 1/4 animals; red anogenital exudate in 1/4 animals; red areas in intestines in 2/4 animals; bloated intestines in 1/4 animals; stomach covered with blue-white dots in 1/4 animals; dark liver in 1/4 animals; mottled liver in 2/4 animals; dark lungs in 2/4 animals; dark kidney in 1/4 animals; dark spleen in 1/4 animals; skin edema
in 1/4 animals; skin redness in 1/4 animals; and blood in urine in 2/4 animals. - Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Based on this test, the substance is not classified
according to EU GHS criteria and classified Acute. Tox. Cat. 5, H313 according to GHS UN criteria.
- Executive summary:
In an acute dermal toxicity study (Moreno, 1978), groups of 4 rabbits (sex unspecified) were dermally exposed to guaiacol at doses of 2500, 3530 and 5000 mg/kg bw.
Dermal LD50 = 4600 mg/kg bw (95% C.I: 3800-5400 mg/kg).
Guaiacol is not classified based on the LD50 of 4600 mg/kg bw/day identified in this study and according to EU classification criteria (Annex VI of Directive 67/548/EEC and Annex I of Regulation (EC) n°1272/2008).
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