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EC number: 411-380-6 | CAS number: 147315-50-2 CG 30-1577
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-06-24 - 1992-08-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
- EC Number:
- 411-380-6
- EC Name:
- 2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
- Cas Number:
- 147315-50-2
- Molecular formula:
- C27 H27 N3 O2
- IUPAC Name:
- 2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-(hexyloxy)phenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino rats (Tif: RAI f (SPF))
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CIBA-GEIGY Limited, Animal Production, Stein, Switzerland
- Weight at study initiation: 181 - 210 g
- Housing: Group-housed in Macrolon cages type 4 with standardized soft wood bedding; animals were identified with numbers from 1 to 5 using picric acid stain on the fur
- Diet: Standard diet, ad libitum
- Water: Fresh water, ad libitum
- Acclimation period: At least for 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 +/- 2 °C
- Humidity: 55 +/- 10 %
- Air conditioning: 15 air changes per hour
- Photoperiod: 12 hour/day light cycle
IN-LIFE DATES: From: 1992-07-14/1992-07-27 To: 1992-07-28/1992-08-10
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 % (w/v) carboxymethylcellulose in 0.1 % (w/v) aqueous polysorbate 80
- Details on oral exposure:
- VOLUME APPLIED: 20 mL/kg bw
- Doses:
- 2000 mg/kg bw (males and females)
- No. of animals per sex per dose:
- 5 rats
- Control animals:
- other: not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Observations and records:
Mortality: daily
Signs and symptoms: daily
Body Weight: immediately before application and on days 7 and 14
- Necropsy of survivors performed: yes - Statistics:
- Body weight: Group means and standard deviations
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The following death rate was observed: 0 % at 2000 mg/kg.
- Clinical signs:
- other: Piloerection, hunched posture, and dyspnea were seen, being common symptoms in acute tests. Additionally, reduced locomotor activity was observed in all animals. The animals recovered within 6 to 7 days.
- Gross pathology:
- A spotted thymus was found in one female. No deviations from normal morphology were found in the remaining animals.
Any other information on results incl. tables
Based on the observations, oral LD50 value was to be greater than 2000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In an acute oral toxicity study groups of male and female rats (5/sex) were given a single oral gavage dose of the test item (as described in section 1.2) in a standard vehicle at a limit dose of 2000 mg/kg bw and observed for 14 days. No mortality occurred. Piloerection, hunched posture, and dyspnea were seen, being common symptoms in acute tests. Additionally, reduced locomotor activity was observed in all animals. The animals recovered within 6 to 7 days. The body weight gain of the animals was not affected. A spotted thymus was found in one female. No deviations from normal morphology were found in the remaining animals. Based on these observations, the oral LD50 value of the test item was greater than 2000 mg/kg bw.
Oral LD50: > 2000 mg/kg bw (per sex and combined)This study is classified as acceptable. It satisfies the guideline requirement for an acute oral toxicity study according to OECD 401.
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