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EC number: 203-472-8 | CAS number: 107-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: summary
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: EPA summary
Data source
Reference
- Reference Type:
- publication
- Title:
- HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROACETALDEHYDE
- Author:
- U.S. ENVIRONMENTAL PROTECTION AGENCY; CINCINNATI, OH 45268
- Year:
- 1 986
- Bibliographic source:
- EPA/600/X-86/151
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chloroacetaldehyde
- EC Number:
- 203-472-8
- EC Name:
- Chloroacetaldehyde
- Cas Number:
- 107-20-0
- Molecular formula:
- C2H3ClO
- IUPAC Name:
- 2-chloroacetaldehyde
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: no bioaccumulation expected due to high reactivity of CAA
Pertinent data regarding the absorption, distribution or excretion of chloroacetaldehyde could not be located in the available literature.
Chloroacetaldehyde is a major metabolite of a number of chlorinated compounds (U.S. EPA, 1980a). After oral administration to rats,
chloroacetaldehyde is first conjugated with glutathione and subsequently metabolized along two pathways (Green and Hathllay. 1977).
Urinary metabolites include N-acetyl(2-hydroxyethyl) cysteine, S-(carboxymethyl) cysteine and thiodiglycollic acid. - Executive summary:
Chloroacetaldehyde is a metabolite of a variety of halogenated organics (U.S. EPA. 1980a), which have received considerable study (Guengerich et a1. 1980; Gwinner et a1.1983). The only metabolism study in which chloroacetaldehyde itself was administered to experimental animals was done by Green and Hathway (1977). Four adult Alderly-Park male rats were administered a 50 mg/kg aqueous solutlon of chloroacetaldehyde by gavage. An unspecified number of control animals was also used. Collected urine was divided for analysis into acetic acid and HCl fractions. The former fraction was analyzed by GC-mass spectometry and mass fragmentography for N-acetyl-S-( 2-hydroxyethyl) cysteine, and the HCl fraction was analyzed by GC-mass spectometry for thiodiglycollic and chloroacetic acids.
The results allowed Green and Hathway (1977) to propose a scheme for the metabolism of chloroacetaldehyde (the scheme is a portion of a more detailed metabolic pathway for vinyl chloride metabolism). Mass fragmentography revealed the presence of N-acetyl-S(2-hydroxyethyl) cysteine and S-(carboxymethyl) cysteine, but not chloroacetic acid, In the urine of separate group of rats led to a thiodiglycollic yield of only 0.5%. Green and Hathway (1977) therefore deduced that S-(carboxymethyl) cysteine was metabolized by a route independent of N-acetyl-S-(2-hydroxyethyl) cysteine, after chloroacetaldehyde administration.
Chloroacetaldehyde is conjugated to glutathione, to yield S-formylmethylglutathione. Further degradation and glutathionase activation results in the appearance of N-acetyl-S-(2-hydroxyethyl) cysteine. Alternatively, S-formyl-methylglutathione can be dehydrogenated and acted upon by liver and kidney glutathionases to yield S-(carboxymethyl) cysteine. Transamination followed by oxidative decarboxylation then leads to the major urinary metabolite, thiodiglycollic acid. The three urinary metabolites observed after oral chloroacetaldehyde administration in rats were thiodiglycollic acid, S-(carboxymethyl) cysteine and N-acetyl-S-(2-hydroxyethyl) cysteine (Green and Hathway, 1977). No other information regarding other routes of elimination was located in the available literature.
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