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Diss Factsheets
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EC number: 909-044-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There no data available on -phosphonic ester residue with respect to irritating effects on skin and mucous membranes (eyes).
There is one component which is evaluated as corrosive and classified with H314 = causes severe skin burns and eye damage. Its content in the mixture is about 30 %.. Therefore, there is no need to conduct a studies on skin irritation/corrosion or eye irritation with phosphonic ester residue because the available information indicates that the criteria are met for classification phosphonic ester residue as corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: secondary citation in a peer Review based on a guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg/patch
- Duration of treatment / exposure:
- 3 min and 4 hours
- Observation period:
- according to guideline: no details given
- Number of animals:
- according to guideline: no details given
- Details on study design:
- according to the respective guideline
- Irritation parameter:
- other: the sloggy test substance was evaluated corrosive
- Basis:
- other: the sloggy testsubstance was evaluated corrosive
- Time point:
- other: 3 min or 4 hours, respectively
- Reversibility:
- other: the sloggy testsubstance was evaluated corrosive
- Remarks on result:
- other: no details given
- Irritant / corrosive response data:
- the test substance was evaluated corrosive
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- Classification: highly corrosive (causes severe burns)
- Executive summary:
Phosphonic acid is tested for skin irritation according to OECD TG 403 and revealed to be corrosive.
ECB (2000):
SO-Freetext: Hoechst AG Frankfurt/Main
Hoechst AG Frankfurt/Main
Clariant GmbH Frankfurt am Main:Only the sloggy product was corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Additional information
There no data available on -phosphonic ester residue with respect to irritating effects on skin and mucous membranes (eyes).
Phosphonic ester residue contains monomethyl phosphonate, phosphonic acid, and Dimethylphosphonate, salt of pyrophosphoric acid. and phosphate which were not further specified
SKIN IRRITATION / CORROSION
Monomethylphosphonate
750 µg of the test substance was applied to the skin of rabbits for 24 hours. The substance caused severe irritation effects (Marhold 1986)
Phosphonic acid
Phosphonic acid is tested for skin irritation according to OECD TG 404 and revealed to be corrosive. According to 67/548 EEC the compound is labelled with H314 = causes severe skin burns and eye damage.
Dimethylphosphonate
In a limited study for skin irritation dimethylphosphonate was applied to the inner surface of an ear of rabbits for 4 hours and after washing observed for further 7 days.On the basis of the results of this study it can be concluded that dimethyl phosphionate is not a skin irritant. Futhermore, the prolongation of the exposure period up to 8 hours did not show relevant irritation effects of the test item on the skin All together the above described results show that dimethyl phophonate is not a skin irritant
Salt of pyrophosphoric acid and phosphate(not further specified)
There are no data available
OVERALL EVALUATION OF SKIN IRRITATION / CORROSION
There are no data on skin irritation property of the residue. However, there is one component which is evaluated as corrosive and classified legally with H314 = causes severe skin burns and eye damage. Its content in the mixture is about 30 %.. According to Regulation (EC) 1972/2008 GHS/CLP section 3.2.3.3.6. a mixture containing a corrosive ingriedient with more than 5 %, this mixture has to be evaluated as corrosive to the skin. Thus, according to Regulation (EC) 1907/2006 (REACh) ANNEX VII section 8.1 column 2 there is no need to conduct a studies on skin irritation/corrosion with phosphonic ester residue because the available information indicates that the criteria are met for classification phosphonic ester residue as corrosive to the skin
EYE IRRITATION / CORROSION
Monomethylphosphonate
no data on eye irritation/corrosion available
Phosphonic acid
There are no data on eye irritation/corrosion: the substance is classified/labelled with H314 = causes severe skin burns and eye damage
Dimethylphosphonate
For eye irritation one reliable study exists using a method similar to OECD guideline 405 with deviations (No GLP study, only 2 animals were used,. no information about environmental and housing conditions). Animals were observed for 7 days. Irritation was scored according to the method of Draize. Reddening of the conjunctiva (grade 2) was observed 1h after treatment; no other effects were observed. Effects were reversible within 5 days. Based on the data available, it can be concluded that dimethyl phosphonate is not irritating to eyes.
Salt ofpyrophosphoric acid and phosphate (not further spedified)
no data available on eye irritatio/corrosion
OVERALL EVALUATION ON EYE IRRITATION
There are no data available evaluating the irritating effect on mucous membranes. According to Regulation (EC) 1907/2006 ANNEX VII section 8.2. column 2 there is no need to conduct a sudy because the available information indicates that the criteria are met for classification as corrosive to the skin.
Justification for selection of skin irritation / corrosion endpoint:
There are no data on skin irritation property of the residue. However, there is one component (Phosphonic acid) which is evaluated as corrosive and classified with H314 = causes severe skin burns and eye damage. Its content in the mixture is 30 %. According to Regulation (EC) 1972/2008 GHS/CLP section 3.2.3.3.6. a mixture containing an ingriedient with more than 5 % this mixture has to be evaluated as corrosive to the skin. Thus, according to Regulation (EC) 1907/2006 (REACh) ANNEX VIII section 8.1 column 2 there is no need to conduct further studies on skin irritation/corrosion because the substance is classified as corrosive.
Justification for selection of eye irritation endpoint:
There are no data with phosphonicester residue available evaluating the irritating effect on mucous membranes. According to Regulation (EC) 1907/2006 ANNEX VII section 8.2. column 2 there is no need to conduct a sudy because the critera are met for classification phosphonic ester residue as corrosive to the skin.
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
According to Regulation (EC) 1972/2008 GHS/CLP section 3.2.3.3.6. a mixture containing a corrosive ingredient with more than 5 %, phosphonic ester residue has to be evaluated as corrosive to the skin and to be classified and labelled accordingly.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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