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EC number: 914-920-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Modification of metal-induced micronuclei formation in mouse bone marrow erythrocytes by Phyllanthus fruit extract and ascorbic acid
- Author:
- Roy, A. K. et al.
- Year:
- 1 992
- Bibliographic source:
- Toxicology Letters 62: 9-17
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Animals were treated with aluminium sulphate and the frequency of micronucleated cells were determined.
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 7784-31-8
- Cas Number:
- 7784-31-8
- IUPAC Name:
- 7784-31-8
- Details on test material:
- - Name of test material (as cited in study report): aluminium sulphate Al2(SO4)3x18H2O from Sarabhai M. Chemicals, India
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: laboratory bred
- Age at study initiation: 6 weeks
- Diet: commercial pellet, ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±2
- Humidity (%): 50± 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: physiol. saline
- Duration of treatment / exposure:
- two single treatments
- Frequency of treatment:
- daily, every 24 h
- Post exposure period:
- 24 and 48 h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 250, 500 mg Al2(SO4)3x18H2O/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 12
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- mitomycin C
- Route of administration: intraperitoneal injection
- Doses / concentrations: 1.5 mg/kg bw
Examinations
- Tissues and cell types examined:
- Tissue: bone marrow
Celly type: bone marrow cells - Details of tissue and slide preparation:
- METHOD OF ANALYSIS:
One thousand polychromatic erythrocytes (PCEs) were scored per animal for determining the frequency of micronucleated cells. In each optic field, a total of 1000 normochromatic erythrocytes (NCEs) were also counted in order to calculate the ratio of NCEs to PCEs to evaluate cytotoxic effects, if any. - Statistics:
- Analysis was carried out following the two-way ANOVA test (with replication) and Duncan´s multiple range test to compare the significance of difference, if any, amongst the different experimental sets.
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- positive
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
The frequency of micronucleated cells increased with increasing doses of aluminium sulphate. The increase was significant (p < 0.05) only with the higher concentration (500 mg/kg bw) of the test chemical.
Table 1. Effect of intraperitoneally administered aluminium sulfate on the frequency of PCEs in bone marrow of cells of mice
Treatment group |
Dose [mg/kg] |
Harvest time [h] |
Mean frequency of PCE with MN
|
NCE/PCE ratio |
Vehicle control |
0 |
24 |
0.23±0.06 |
0.98±0.02 |
|
0 |
48 |
0.17±0.06 |
1.01±0.02 |
Test substance |
250 |
24 |
0.50±0.11 |
1.01±0.01 |
|
250 |
48 |
0.43±0.16 |
1.01±0.01 |
Test substance |
500 |
24 |
1.23±0.10 |
1.01±0.02 |
|
500 |
48 |
1.13±0.16 |
1.01±0.01 |
Positive control (Mitomycin) |
1.5 |
24 |
2.30±0.18 |
1.04±0.02 |
|
1.5 |
48 |
2.27±0.16 |
1.05±0.02 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): positive
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