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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 690-526-2 | CAS number: 38632-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Based on the results of the developmental toxicity study the substance will be labeled with “Repr. Cat. 1b” according to GHS. Consequently, no further testing is warranted to investigate fertility.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Based on the results of the developmental toxicity study the substance will be labeled with “Repr. Cat. 1b” according to GHS. Consequently, no further testing is warranted to investigate fertility.
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Based on the results of the developmental toxicity study the substance will be labeled with “Repr. Cat. 1b” according to GHS. Consequently, no further testing is warranted to investigate fertility.
Additional information
Based on the results of the developmental toxicity study the substance will be labeled with “Repr. Cat. 1b” according to GHS. Consequently, no further testing is warranted to investigate fertility.
Short description of key information:
Based on the results of the developmental toxicity study the substance will be labeled with “Repr. Cat. 1b” according to GHS. Consequently, no further testing is warranted to investigate fertility.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 232 mg/kg bw/day
- Species:
- rat
- Quality of whole database:
- Guideline developmental toxicity study according to OECD 414 and GLP.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The NOAEL (No-Observed-Adverse-Effect-Level) for maternal effects was 250 mg/kg body weight/day based on reduced body weight, body weight gains and food consumption in the 1000 mg/kg body weight/ day dose group.
Based on the increased incidence of fetal abnormalities found during visceral and skeletal examinations in the 1000 mg/kg body weight/ day dose group, the NOAEL for prenatal morphological alterations including teratogenicity was considered to be the mid dose, 250 mg/kg body weight/day (achieved dose level 231.7 mg/kg body weight/ day).
Justification for classification or non-classification
Based on the data of the delelopmental toxicity the compound will be classified with Repr. cat 2, R61 according to the EU classification criteria 67/548/EWG and Repr. 1b (H360) according to regulation no. 1272/2008 (GHS).
According to the ECHA guidance on the application of the CLP criteria, Version 3, dated November 2012 the compound will be allocated to the medium potency group (ED10 between 4 and 400 mg/kg/day) and, consequently, the "General Concentration Limits" according to regulation 1272/2008 (GHS) apply for this compound.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.