Registration Dossier
Registration Dossier
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EC number: 410-510-9 | CAS number: 86753-82-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar derived
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Remarks:
- deionised
- Duration of exposure:
- 24h
- No. of animals per sex per dose:
- male:5
female:5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
Mortality
male:>2000mg/kg bw; number of animals 5; number of deaths 0
female:>2000mg/kg bw; number of animals 5; number of deaths 0
Clinical signs
Signs of toxicity related to dose levels: no significant signs of systematic toxicity.
Gross pathology
Effects on organs: no significant substance related effects were observed at post mortem.
Other findings
Signs of toxicity (local): the skins of all animals were stained orange/yellow for 6 days after appliction which prevented a full assessment of the erythema. There was evidence of slight irritation at the application site of the majority of the animals for up to 2 days after application.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- dermal LD50 > 2000mg/kg bw
- Executive summary:
Not classified. No deaths occurred during the observation period. No significant clinical effects were observed.Signs of slight irritation on application site were not observed anymore, after 2 days.
LD50 >2000mg/kg bw.
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