Registration Dossier
Registration Dossier
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EC number: 807-374-1 | CAS number: 2540-36-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Reference Type:
- publication
- Title:
- Sodium ethyl xanthate. Priority existing chemical no. 5. NICNAS
- Author:
- Australian Government Publishing Service
- Year:
- 1 995
- Bibliographic source:
- Australian Government Publishing Service
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- This study predates the requirements for good laboratory practice, however the study was considered adequate for this assessment
Test material
- Reference substance name:
- sodium ethyl xanthate
- IUPAC Name:
- sodium ethyl xanthate
- Reference substance name:
- CAS# 140-90-9
- IUPAC Name:
- CAS# 140-90-9
- Test material form:
- other: 10% water solution of sodium ethyl xanthate (CAS# 140-90-9)
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- other: albino
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 730 mg/kg bw
- Clinical signs:
- other: The target organs for oral toxicity of SEX were the central nervous system, liver and spleen. The majority of death occurred on the first day, and the animals that survived appeared normal within two days
- Gross pathology:
- Depression followed by hyperexcitability, tremors, paralysis exophtaalmia and clonic followed by tonic convulsions.
Pinkness of feet and nose, preening and salivation. Consolidated lungs, pale granular livers, unusually small spleens and atonic intestine.
Surviving animals showed no abnormalities
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
