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Diss Factsheets
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EC number: 202-443-7 | CAS number: 95-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment; pre-GLP study.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Guinea Pig induction method, company protocol
- GLP compliance:
- no
- Type of study:
- skin painting test
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 441.2 g - Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- Induction: 20% (2 applications); 50% (8 applications)
Challenge: 5%,
Rechallenge: 20% - Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- Induction: 20% (2 applications); 50% (8 applications)
Challenge: 5%,
Rechallenge: 20% - No. of animals per dose:
- 10
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 10 applications
- Test groups: 10 animals
- Control group: 3 animals
- Site: ca. 25 cm2 clipped area of flank
- Frequency of applications: paintings were done three times in a row, for 5 days per week (together ten times in two weeks)
- Concentrations: 20% (2 applications), 50% (8 applications)
B. CHALLENGE EXPOSURE
- No. of exposures: 2
- Day(s) of challenge: first challenge 16 days after induction; second challenge 16 days after first challenge
- Test groups: 10 animals
- Control group: 3 animals
- Site: shaved right flank
- Concentrations: 5% (challenge), 20% (rechallenge)
- Evaluation (hr after challenge): 12 h - Challenge controls:
- Not treated during induction period
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Hours after challenge:
- 12
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 12.0. Group: test group. Dose level: 5%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- rechallenge
- Hours after challenge:
- 12
- Group:
- test chemical
- Dose level:
- 20%
- No. with + reactions:
- 7
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 12.0. Group: test group. Dose level: 20%. No with. + reactions: 7.0. Total no. in groups: 10.0.
- Reading:
- 1st reading
- Hours after challenge:
- 12
- Group:
- negative control
- Dose level:
- 5%
- No. with + reactions:
- 0
- Total no. in group:
- 3
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 12.0. Group: negative control. Dose level: 5%. No with. + reactions: 0.0. Total no. in groups: 3.0.
- Reading:
- rechallenge
- Hours after challenge:
- 12
- Group:
- negative control
- Dose level:
- 20%
- No. with + reactions:
- 0
- Total no. in group:
- 3
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 12.0. Group: negative control. Dose level: 20%. No with. + reactions: 0.0. Total no. in groups: 3.0.
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
The test substance was judged to be slightly sensitizing by the authors.
1) Induction:
Repeated application of the test substance at 20% or 50% in acetone produced hemorrhagic encrustations in 10/10 animals of the test group. These symptoms were reversible within the 16-day rest period.
2) Challenge / rechallenge:
Single application of the 5% solution in acetone to the previously untreated site did not produce any skin response in the animals of the test group. In contrast, application of the 20% solution at 16 days later produced a slight erythema in 7/10 test animals. Control animals did not show any skin response after treatment with either 5% or 20%.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The experimental data for hydroquinone is not provided. It is referred to the legal classification of hydroquinone in the EU (Annex I index no. 604 -005 -00 -4).
Migrated from Short description of key information:
Both trimethylhydroquinone (CAS 700-13-0) and hydroquinone (CAS 123-31-9) cause skin sensitization in experimental animals. Therefore, 2-methylhydroquinone is classified for skin sensitization without further testing.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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