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EC number: 700-627-6 | CAS number: 17270-01-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented and reported study fully adequate for assessment. The study was conducted according to internationally accepted technical guidelines and in compliance with GLP in a recognized contract research organization.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- of 2002
- Deviations:
- no
- Remarks:
- Inadvertently 14 h artificial light per 24 h, instead of 12 h per 24 h did not compromise the study results
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- of 2008
- Deviations:
- no
- Remarks:
- Inadvertently 14 h artificial light per 24 h, instead of 12 h per 24 h did not compromise the study results
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Version / remarks:
- of 1998
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese MAFF Test Data for Registration of Agricultural Chemicals, Skin Irritation (2-1-4), 12 Nohsan No. 8147, Agricultural Production Bureau, November 24, 2000.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4'-[(diphenoxyphosphoryl)oxy]-[1,1'-biphenyl]-4-yl diphenyl phosphate
- EC Number:
- 700-627-6
- Cas Number:
- 17270-01-8
- Molecular formula:
- C36H28O8P2
- IUPAC Name:
- 4'-[(diphenoxyphosphoryl)oxy]-[1,1'-biphenyl]-4-yl diphenyl phosphate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Stock supply of healthy adult rabbits
- Number and Sex: 3 females
- Age on day of dosing (Day 1): 40 - 45 weeks
- Weight prior to dosing (Day 1): Minimum 3.83 kg, maximum 4.25 kg
- Housing: Individual housing in plastic cages with peforated floor
- Environmental enrichment: Small soft white untreated wood blocks
- Diet : Standard laboratory rabbit diet (125 g/animal/day). In addition, dietary supplement of hay.
- Water: Drinking water, ad libitum
- Acclimation period: 22 to 26 weeks prior to study start under laboratory conditions.
Routine analysis of the batch of diet used for nutrients, possible contaminants and microorganisms and of the drinking water were conducted or available at the testing facility.
ENVIRONMENTAL CONDITIONS
Air conditioned animal room set at:
- Temperature (°C): 18 ± 2°C
- Relative Humidity (%): 40 to 70%
- Photoperiod: 14 hrs artificial light per 24 hrs
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: On the day before exposure removal of hair from the dorsolumbar region by use of clippers
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Treatment site was moistened with 0.5 mL reverse osmosis water
- Controls:
- not required
- Amount / concentration applied:
- ca. 0.5 g of the test material per 2.5 cm x 2.5 cm clipped intact skin per animal.
- Duration of treatment / exposure:
- Animal # 3 (sentinel animal): Three exposures of 3 minutes, 1 hour or 4 hours in sequential order to act as a preliminary screen.
Animals # 1 & 2: 4 hours - Observation period:
- 72 hours post patch removal
- Number of animals:
- 3 females
- Details on study design:
- TEST SITE PREPARATION:
On the day before treatment, hair was removed with clippers from the dorsolumbar region of each animal. The neat test substance was administered under a 2-ply 25 mm x 25 mm porous gauze pad secured with 'blenderm' surgical tape to intact skin sites moistened with 0.5 mL reverse osmosis water. For exposures of one hour or more each treatment site was covered additionally with cotton wool and "Tubigrip" elasticated bandage dressing for the duration of the exposure period.
On each animal an additional site was similarly treated with the exception of test substance and acted as a control.
TREATMENT PERIOD AND REMOVAL OF TEST SUBSTANCE
At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and the treatment site was washed with lukewarm water (30-40°C) to remove any residual test substance. The treated area was blotted dry with absorbent paper.
SKIN EVALUATION:
The treated skin patches were evaluated immediately after patch removal (for 3 minute and 1 hour exposures) and at 1, 24, 48 and 72 h afterwards, whereby only the data for the 4 hour exposures were reported. The scoring system for the grading of skin reactions is listed in Table 1 (next field below).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- as defined in Table 1
- Basis:
- mean
- Remarks:
- over 3 animals and 3 time points
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: erythema or eschar formation was not evident
- Irritation parameter:
- edema score
- Remarks:
- as defined in Table 1
- Basis:
- mean
- Remarks:
- over 3 animals and 3 time points
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: edema formation was not evident
- Irritant / corrosive response data:
- In each animal, erythema, eschar or edema formation or any other skin reactions were not evident at any observation time point of the study, i.e. not evident at 1, 24, 48 or 72 hours after the end of administration.
- Other effects:
- Signs of systemic toxicity or ill health were not evident.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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