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EC number: 434-800-1 | CAS number: 121776-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 23 Feb, 1990 to April 2, 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Relative humidity was outside the range specified in the guideline but it did not impact the results outcome.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 434-800-1
- EC Name:
- -
- Cas Number:
- 121776-33-8
- Molecular formula:
- C11H13CL2NO3
- IUPAC Name:
- 2,2-dichloro-1-[5-(furan-2-yl)-2,2-dimethyl-1,3-oxazolidin-3-yl]ethan-1-one
- Reference substance name:
- 3-(Dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine
- IUPAC Name:
- 3-(Dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): MON 13900
- Physical state: Brown particles (powder)
- Lot/batch No.: DAY-8912-1370T
- Expiration date of the lot/batch: December, 1993 (est)
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female young adult Sprague Dawley rats used in this study were obtained from Charles River Laboratories, Inc. (Portage, Michiganand Raleigh, North Carolina). The animals were individually housed in suspended stainless steel cages in an environment-controlled room with a 12-h light/dark cycle. Agway Prolab rodent feed and water were provided to each animal ad libitum. The rats were individually identified using metal ear tags and cage cards. All animals were allowed to acclimate to the laboratory environment for a minimum of 5 d prior to dosing.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test substance was ground and passed through a 40 mesh sieve prior to mixing with Mazola Corn Oil at a 25% w/v concentration. The dose volume administered was varied to achieve the designated mg/kg treatment levels.
- Doses:
- 100, 500, 1000 and 1500 mg/kg bw
- No. of animals per sex per dose:
- 5/dose (males) for 100 and 1500 mg/kg/ bw and 5/sex/dose for 500 and 1000 mg/kg/ bw
- Control animals:
- no
- Details on study design:
- All animals were fasted overnight prior to dose administration. The animals were observed frequently on the day of dosing and once daily thereafter for the duration of the study (Day 15). Mortality checks were performed twice daily. Individual body weights were determined and recorded on Days -1, 1, 8 and 15, or at death. All animals were subjected to a gross necropsy examination at the time of sacrifice (CO2, asphyxiation) or death.
- Statistics:
- LD50 values and 95% confidence intervals were calculated using the method of Litchfield and Wilcoxon.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 250 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.13 - <= 1.21
- Remarks on result:
- other: Slope was 1.17
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 521 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.02 - <= 2.4
- Remarks on result:
- other: Slope was 1.57
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 869 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.51 - <= 3.1
- Remarks on result:
- other: Slope was 2.17
- Mortality:
- All deaths in the LD50 animals occurred by study Day 5.
- Clinical signs:
- other: A variety of adverse clinical signs was observed in the LD50 study animals. The majority of the clinical signs occurred during study Days 1-5. The most notable clinical signs included decreased fecal output, reddish colored urine and urine stains. Additio
- Gross pathology:
- No remarkable gross internal findings were noted in animals which survived. In animals which died, the most notable findings consisted of colored mucoid/fluid contents in the digestive tract, reddened stomach mucosa, black/red foci on the stomach and dark red foci on thymus.
Any other information on results incl. tables
Results:
Sex |
Calculated LD50 value (mg/kg) |
95% confidence interval (mg/kg) |
Slope |
95% confidence interval |
Males |
521 |
428-634 |
1.17 |
1.13-1.21 |
Females |
1250 |
840-1858 |
1.57 |
1.02-2.43 |
Combined |
869 |
566-1333 |
2.17 |
1.51-3.12 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the test conditions, the acute oral LD50 of MON 13900 for male and females rats was calculated to be 521 and 1,250 mg/kg bw respectively. The combined LD50 for both the sexes was calculated to be 869 mg/kg bw.
- Executive summary:
A study was performed to assess theacute oral toxicityof MON 13900 in SD rat according to the EPA OPP 81-1 Guideline in compliance with GLP. Group of rats (5/dose for lowest and the highest dose and 5/sex/dose for the middle doses) were administered the test substance at 100, 500, 1,000 and 1,500 mg/kg bw.
A variety of adverse clinical signs were noted, including decreased fecal output, reddish coloured urine, urine stains, decreased activity, tremors, breathing abnormalities, piloerection and apparent hypothermia. The majority of these signs occurred during Days 1-5. All surviving animals exhibited body weight gains during the test period. The most notable necropsy observations occurred in the animals which died and consisted of abnormalities of the digestive tract and thymus.
Under the test conditions, the acute oral LD50 of the test substance for male and females rats was calculated to be 521 and 1,250 mg/kg bw respectively. The combined LD50 for both the sexes was calculated to be 869 mg/kg bw.
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