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EC number: 935-847-3 | CAS number: 1369773-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1-25 Sep 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- During the limit test samples for analysis were taken from both the limit concentration and the control according to the schedule below.
Frequency at t=O h, t=24 h and t=72 h
Volume 2ml
Storage Samples were stored in a freezer until analysis.
At the end of the exposure period, the replicates with algae were pooled at each concentration before sampling. - Vehicle:
- yes
- Remarks:
- M2
- Details on test solutions:
- The standard test procedures required generation of test solutions, which contained completely
dissolved test substance concentrations or stable and homogeneous mixtures or dispersions.
The testing of concentrations that would disturb the test system was prevented as much as
possible (e.g. film of the test substance on the water surface).
The batch of AHU377 C9 tested was a white powder with a purity of 99.82% and completely
soluble in test medium at the concentrations tested.
Preparation of the test solution started with a loading rate of 100 mg/I applying 25 minutes of
magnetic stirring followed by a 10-minute treatment period with ultrasonic waves to accelerate
the dissolving of the test substance in the test medium. The final test solution was all clear and
colourless.
After preparation, volumes of 50 ml were added to each replicate of the respective test
concentration. Subsequently, 1 ml of an algal suspension was added to each replicate providing
a cell density of 10E4 cells/ml. - Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Pseudokirchneriella subcapitata, strain: NIVA CHL 1
This system is an unicellular algal species sensitive to
toxic substances in the aquatic ecosystem and has
been selected as an internationally accepted species. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Test temperature:
- 21-24°C
- pH:
- 6.0-9.0
- Reference substance (positive control):
- no
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- < 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield inhibition
- Validity criteria fulfilled:
- yes
- Conclusions:
- AHU377 C9 did not reduce growth rate of this fresh water algae species at 100 mg/l (NOEC). Yield inhibition was statistically inhibited by 17% (NOEC < 100 mg/l). The EC50s of or both growth rate reduction (ERC50: 0-72h) and yield inhibition (ERC50:0 -72h) was beyond 100 mg/l.
- Executive summary:
AHU377 C9 did not reduce growth rate of this fresh water algae species at 100 mgl/l (NOEC). Yield inhibition was statistically inhibited by 17% (NOEC < 100 mg/l). The ECsof or both growth rate reduction (ERC50: 0-72h) and yield inhibition (ERC500 -72h) was beyond 100 mgl/l.
Reference
Description of key information
AHU377 C9 did not reduce growth rate of this fresh water algae species at 100 mgl/l (NOEC). Yield inhibition was statistically inhibited by 17% (NOEC < 100 mg/l). The EC50 for both growth rate reduction (ERC50: 0-72h) and yield inhibition (ERC50
0 -72h) was beyond 100 mgl/l.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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