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EC number: 609-201-3 | CAS number: 36062-04-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Title:
- Unnamed
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- Cas Number:
- 36062-04-1
- Molecular formula:
- C21H24O6
- IUPAC Name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- 0.5 g
- Observation period:
- 1, 24, 48, 72 hours
- Number of animals:
- 1
Results and discussion
In vivo
Results
- Remarks on result:
- other: Information provided in full study report
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Since the mean score of erythema and oedema did not qualify for any of the classification criteria, Tetrahydrocurcuminoids is classified as per the Harmonised Integrated Classification system (14 th August 2001) as "Not Irritant" to the rabbit skin.
- Executive summary:
The acute Dermal Irritatino /Corrosion Study in Newzealand White Rabbits with Tetrahydrocurcuminoids was investigated according to OECD guideline No. 404. The test item was applied by topical semi-occlusive application of 0.5 g to the intact left flank of a single male rabbit. As no severe skin reactions were observed after the 4 -hour exposure and thereafter till 48 hours (approximately), the test was completed using remaining two male rabbits for an exposure period of 4 hours.
The scoring of skin reactions were performed at 1, 24, 48 and 72 hours after exposure (removal of the dressing, gauze patch and test item), for all the rabbits.
The test item did not elict any skin reaction at the application site of Animal No. 01 at 1 hour observation, revealed slight erythema at 24 and 48 hour observation and appeared normal at 72 hour observation. The test item did not elicit any skin reactions at the application site of Animal No. 02 and 03 at any of the observation time points. Oedema was not obseved in any of the treated animals at 1, 24, 48 and 72 hours observation. The individual mean score for erythema /eschar and oedema for each of the three male rabbits were therefore 0.67, 0.0, 0.0 and 0.0, 0.0, 0.0 respectively.
The application of Tetrahydrocurcuminoids to the skin did not result in severe signs of irritaion. The test item did not cause staining of the treated skin. No clinical signs were observed in any of the animals throughout the acclimatization as well as the observation period after treatment. Body weight of all animals considered within the normal range according to the species and strain.
At necropsy, no gross macroscopic abnormalitites were observed in Animal No. 01 and 02. In Animal No. 03, at the control site (right flank), 2 -3 foci (approx 4 mm) of epidermal ulceration with scab formation was observed. Since the lesion was observed in control site, this incidental and may not be due to the test item.
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