Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- National toxicology program technical report series no. 310: Toxicology and carcinogenesis studies of marine diesel fuel and JP-5 navy fuel in B6C3Fl mice (dermal studies).
- Author:
- NTP
- Year:
- 1 986
- Bibliographic source:
- Research Triangle Park, NC: National Toxicology Program/ National Institutes of Health. NIH publication no. 86-2566.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Subacute Dermal (14-Day) Exposure
- Principles of method if other than guideline:
- Subacute Dermal (14-Day) Exposure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- diesel fuel
- IUPAC Name:
- diesel fuel
- Details on test material:
- Test substance: mixtures of petroleum-derived products: marine diesel fuel (mixture of hydrocarbons containing 12.7% paraffins, 43.7% naphthalenes, and 43.6% aromatic compounds) and JP-5 jet aviation fuel (mixture of hydrocarbons containing 52.8% cycloparaffins, 30.8% paraffins, 15.9% aromatics, and 0.5% olefins)
Constituent 1
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Study observed
Marine Diesel Fuel:
Survival/Mortality:
Up to 8000 mg/kg bw/day: No mortality was observed in both males/females;
At ≥20000 mg/kg bw/day: 100% mortality in both males and females; no animals survived to the end of the study.
Skin effects:
Skin lesions were similar in all treated animals and were characterized by moderate acanthosis, parakeratosis, and hyperkeratosis and were accompanied by moderate mixed cellular inflammatory infiltrate in the upper dermis.
JP-5 navy fuel:
Survival/Mortality:
Up to 20000 mg/kg bw/day: No mortality was observed in both males/females;
At ≥30000 mg/kg bw/day: 100% mortality in females; and at 40000 mg/kg bw/day 100% mortality in males were observed; no animals survived to the end of the study in these dose groups.
Skin effects:
Treatment-related effects at the application site included scaly skin and hiair loss.
Skin lesions were characterized by acanthosis, hyperkeratosis, and acute or subacute inflammation.
Applicant's summary and conclusion
- Conclusions:
- Skin lesions were reported as treatment-related effects on exposure to diesel fuel
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