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EC number: 616-248-3 | CAS number: 75627-31-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 3.9 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 39.2 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.4 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 5.74 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.138 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.014 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 25.3 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The aquatic ecotoxicity database for nonylphenol ethoxylate, sarcosine derivative (CAS number 75627-31-5) is limited to an acute toxicity study with Daphnia magna, an algae toxicity study with Desmodesmus subspicatus and a micro-organisms respiration inhibition study with sewage sludge. Read-across has been used to assess the toxicity to fish and as supporting information for the toxicity to Daphnia.
The acute toxicity data reported for the read-across substance indicate that fish (96h-LC50 = 1.3 mg/L) and Daphnia (48h-LC50 = 1.8 mg/L) are equally sensitive to the substance. The same can be concluded with respect to long term effects for fish (28d-NOEC = 0.1 mg/L) and Daphnia (21d-NOEC = 0.18 mg/L).
The comparison between the effects of the registered substance and the read-across substance reveals that effects of the registered substance (48h-EC50 Daphnia = 3.92 mg /L) occur in the same range as for the read-across substance (48h-EC50 Daphnia = 1.8 mg/L).
Overall it can be concluded that fish and Daphnia are equally sensitive, whereas algea appear less sensitive compared to fish and Daphnia. It can also be concluded that the toxicity of the registered substance is in the same range as the toxicity of the read-across substance. As the toxicity of both substances lies in the same range, it has been preferred to derive the PNEC on the basis of the fully reliable 48h-EC50 Daphnia of 3.92 mg/L determined for the registered substance itself. This figure is based on measured test concentrations and is converted to the active ingredient content.
The hazard assessment for the aquatic compartment is based on the following data:
Result |
Remarks |
Reference |
|
Oncorhynchus mykiss OECD 203 |
96h-LC50 = 1.3 mg/L |
Read-across, Reliability 2, Nominal conc. |
Wetton, 1996 |
Oncorhynchus mykiss OECD215 |
28d-NOEC = 0.1 mg ai/L 28d-LOEC = 0.18 mg ai/L |
Read-across, Reliability 2 Nominal conc. |
Wetton, 1992 |
Daphnia magna OECD 202 |
48h-EC50 = 3.92 mg ai/L* |
Reliability 1 Measured concentration |
Noack, 2013 |
Daphnia magna OECD 202 |
48h-LC50 = 1.8 mg ai/L |
Read-across Reliability 2 Nominal conc. |
Wetton, 1996 |
Daphnia magna 21d OECD 202 (1984) |
21d-NOEC = 0.18 mg ai/L
|
Read-across Reliability 2 Nominal conc. |
Wetton, 1999 |
Desmodesmus subspicatus OECD 201 |
72h-ErC50 > 10.2 mg ai/L 72h-ErC10 = 5.13 mg ai/L |
Reliability 1 Measured concentration |
Scheerbaum, 2012 |
Microorganisms OECD 209
|
3h-EC50 = 421 mg ai/L 3h-EC10 =57.4 mg ai/L |
Reliability 1 Nominal conc.
|
Fiebig, 2012 |
*Figure in bold is used for PNEC derivation
Conclusion on classification
For classification purposes Ecotoxicity, Biodegradability and Bioconcentration have to be considered.
Ecotoxicity
The classification is based on the following aquatic toxicity data:
Fish short term Oncorhynchus mykiss OECD 203 |
96h-LC50 = 1.3 mg/L
|
Read-across Reliability 2 (Wetton, 1996) |
Fish chronic Oncorhynchus mykiss OECD215 |
28d-NOEC = 0.1 mg ai/L 28d-LOEC = 0.18 mg ai/L |
Read-across Reliability 2 (Wetton, 1992) |
Crustaceae short term Daphnia magna OECD 202 |
48h-EC50 = 3.92 mg ai/L |
Reliability 1 (Noack, 2013) |
Crustaceae short term Daphnia magna OECD 202 |
48h-EC50 = 1.8 mg ai/L |
Read-across Reliability 2 (Wetton, 1996) |
Crustaceae chronic Daphnia magna 21d OECD 202 (1984) |
21d-NOEC = 0.18 mg ai/L |
Read-across Reliability 2 (Wetton, 1999) |
Algae short term/chronic Desmodesmus subspicatus OECD 201 |
72h-ErC50 = > 10.2 mg ai/L 72h-ErC10 = 5.13 mg ai/L |
Reliability 1 (Scheerbaum, 2012) |
Biodegradability
The substance is not readily biodegradable and considered stable to hydrolysis under environmental conditions. Therefore the substance is considered to be not rapidly degradable for classification purposes.
Bioaccumulation potential
The log Kow is determined as 3.9 and the calculated BCF amounts 412 L/kg. It can be concluded that these values are close to (but below) the criteria that indicate a potential to bioaccumulate (criteria: log Kow > 4 and BCF > 500).
Conclusion classification according to Regulation (EC) 1272/2008 (CLP)
Acute toxicity data are available for fish (read-across), daphnia and algae. As all acute toxicity values exceed 1 mg/L, the substance is not classified for acute aquatic hazards.
Chronic toxicity data are available only for fish (read-across), Daphnia (read-across) and algae. As algae cannot be designated as the most sensitive species on the basis of the available acute toxicity data, the classification is based on the data that provide the most strict classification. Based on the fully reliable acute toxicity data for the registered substance in combination with information on the substance being not rapid biodegradable, the substance is classified with:
Aquatic hazard Category Chronic 2
M-factor need not be determined as the substance is not classified with Acute Category 1 or Chronic Category 1.
Classification according to 67/548/EEC (DSD)
The lowest acute EC50 values are between 1 – 10 mg/L. As the substance is not readily biodegradable and stable to hydrolysis, the substance is considered not rapidly biodegradable. Therefor the substance is classified with:
N; R51/53
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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