Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-530-4 | CAS number: 129423-54-7 PV-ECHTGELB HGR
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Mutagenicity in bacterial test systems
The test substance Pigment Yellow 191 was evaluated for mutagenicity in the bacterial reverse mutation test (EU method B.13/14) in accordance with GLP. This study was conducted using five strains of Salmonella typhimurium bacteria (TA98, TA100, TA1535, TA1537 and TA1538) with and without metabolic activation. The test substance was not mutagenic up to the tested concentration of 5000 µg/plate.
In vivo mammalian erythrocyte micronucleus test
The test substance was tested for the assessment of cytogenetic damage in vivo, using laboratory rat (Wistar).
The test was performed according to the EU Method B.12, Mutagenicity – In vivo Mammalian Erythrocyte Micronucleus Test. The method is analogous to the OECD Test Guideline No. 474, Mammalian Erythrocyte Micronucleus Test.
The test substance was administered to animals by stomach tube in single dose. Three dose levels were chosen according to the results of pilot experiment - 500, 1000 and 2000 mg/kg of body weight. Two bone marrow sampling intervals were used - 24 and 48 hours after administration. The group of animals without administration and concurrent negative and positive controls were included.
The smears obtained from bone marrow were examined by light microscope. In any dose levels investigated the test substance did not cause a significant increase of count of immature erythrocytes with micronuclei in comparison with negative control group.
Justification for selection of genetic toxicity endpoint
No study was selected, since the conclusion is based on the following assays: Bacterial reverse mutation assay (Ames test) and in vivo mammalian erythrocyte micronucleus test.
Short description of key information:
Gene mutation (reverse mutation assay/Ames test): negative in all tested bacterial strains with and without
metabolic activation (EU B.13/14).
In vivo mammalian erythrocyte micronucleus test: negative, did not give rise to formation of micronuclei in immature erytrocytes in bone marrow of rat (EU B.12/OECD 474).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results of in vitro bacterial gene mutation study and in vivo mammalian erythrocyte micronucleus test no classification is proposed for genotoxicity according to the criteria of CLP regulation 1272/2008 and the EU directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.