Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-581-0 | CAS number: 108-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1989-08-21 till 1989-12-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with no or acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- #28: Biodegradation in water: screening tests
- Author:
- MITI
- Year:
- 1 989
- Bibliographic source:
- http://www.safe.nite.go.jp/jcheck/
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: JIS K 0102-1986, "Test methods for industrial water"
- Deviations:
- not specified
- Principles of method if other than guideline:
- Determination of BOD and measurement of TOC.
Analytical HPLC analysis. - GLP compliance:
- yes
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Test material form:
- other: liquid
- Details on test material:
- - Purity: 99 % ± 1 %
- Empirical formula: C6H6ClN
- Molecular mass: 127.58 g/mole
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- - Source of inoculum/activated sludge:
Fushiko Fluss Behandlungsanlage (Sapporo)
Nakahama Behandlungsanlage (Osaka)
Kitakami (Ishinomaki City, Präfektur Miyagi)
Yoshino River (Tokushima)
Hiroshima Bay (Hiroshima)
Fukashiba Behandlungsanlage (Ibaraki Kashima-gun)
Ochiai Behandlungsanlage (Shinjuku-ku, Tokyo)
Shinano River (Niigata Nishikanbara County)
Biwa-See (Otsu, Shiga Präfektur)
Dokai (Kitakyushu)
- Storage conditions: dark room
- Date of colletion: June 1989
- Preparation of inoculum for exposure:
Were collected from 500 locations in Japan old and new mud. 5 L and 10 L of the old de new activated sludge were mixed and then filtered. The pH was adjusted to 7.0 + / - 1.0 set.
- Concentration of sludge: 30 mg/L suspended solids
- Concentration of suspended solids in the activated sludge: 6800 mg / L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- TOC removal
- Details on study design:
- A solution of 100 mg/L 3-chloroaniline in a mineral medium was stirred in a closed flask (300 mL) and inoculated at a constant temperature (25 ± 1 °C) for up to 28 days under aerobic conditions in the dark.
The endogenous activity of the inoculum was checked running parallel blanks with inoculum but without 3-chloroaniline. A reference compound (aniline) was run in parallel to check the operation of the procedures.
A toxicity control (3-chloroaniline and reference compound) was run parallel, to ensure that the chosen concentration of 3-chloroaniline was not inhibitory to microorganisms.
Degradation was followed by the determination of oxygen uptake and measurement were taken at frequent intervals to allow the identification of the beginning and end of biodegradation.
The oxygen uptake was calculated from the readings taken at regular frequent intervals, using the method given by the manufacturer of the equipment. At the beginning and the end of incubatio, the pH was measured in the flasks.
Exposure condition:
- Test volume: 300 mL
- Test apparatus: Wakosil-5C18
- 28 days incubation at 25 ± 1 °C
Reference substance
- Reference substance:
- aniline
- Remarks:
- (100 mg/L)
Results and discussion
% Degradationopen allclose all
- Parameter:
- other: TOC
- Value:
- 3
- Sampling time:
- 28 d
- Parameter:
- other: TOC
- Value:
- 2
- Sampling time:
- 28 d
- Parameter:
- other: TOC
- Value:
- 4
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- A degradation of 65 % of the reference compound was measured after 7 and 14 days.
Any other information on results incl. tables
From the beginning to the end the pH values of different flasks are in the range og 7.0 to 7.3.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Within 28 days , a degradation rate of 3 % was determined. 3-chloroaniline is considered to be "Not Readily Biodegradable". The refence compound aniline showed 65 %.
- Executive summary:
Within 28 days , a degradation rate of 3 % was determined. 3-chloroaniline is considered to be "Not Readily Biodegradable". The refence compound aniline showed 65 %.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.