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EC number: 627-872-0 | CAS number: 1514-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 August 2002 - 14 January 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD and US EPA test guidelines, and in compliance with GLP; on this basis the result is considered reliable without restriction.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-bromo-3,3,3-trifluoroprop-1-ene
- EC Number:
- 627-872-0
- Cas Number:
- 1514-82-5
- Molecular formula:
- C3H2BrF3
- IUPAC Name:
- 2-bromo-3,3,3-trifluoroprop-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 2-Bromo-3,3,3-trifluoropropene (CAS 1514-82-5)
- Physical state: Colourless volatile liquid
- Analytical purity: ≥99.5%
- Lot/batch No.: KGA154-2B
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Group 1: Target 25,000 ppm, Analytical 26,580 ppm, Nominal 29,400 ppm
Group 4: Target 5,000 ppm, Analytical 5,173 ppm, Nominal 6,220 ppm - No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 11 726 ppm
- Based on:
- test mat.
- 95% CL:
- 9 054 - 15 186
- Exp. duration:
- 4 h
- Mortality:
- 26,580 ppm: 10/10 died
5,173 ppm: 0/10 died - Clinical signs:
- other: During exposure, labored breathing or gasping was reported during the last hour of each exposure. Immediately following the exposures, clear or red nasal discharge, excessive salivation, labored breathing and mosit rales were observed. The severity and
- Body weight:
- All surviving animals gained weight (or did not lose weight) during both weeks of observation.
- Gross pathology:
- One or more rats from both exposure levels had red discoloration of the lungs. Fluid was present in the lungs of one male fromt he higher level exposure of 26,580 ppm. Microscopically, in the unscheduled deaths, the discoloration was due to vascular congestion which is commonly seen in rats not found dead or moribund rior to post mortem examination. The scattered red foci were agonal hemorrhages. All of the rats in the 26, 580 ppm group had bronchiolar lesions consisting of desquamated epithelium, bronchiolar/peribronchiolar acute/subacute inflammation and/or intraluminal debris; the severity of the findings ranged from slight to moderate. Alveolar/intralveolar macrophages (minimal to moderate) normally present in lungs, were most numerous in several of these rats. Other findings in the lungs ocurred sporadically and were not considered to be test substance related. these findings have been seen in rats of this strain and age used in similar studies conducted at this facility.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4-hr acute inhalation toxicity in rats was 11,726 ppm.
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