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Reaction mass of endo-2-methyl-exo-3-methyl-exo-2-[(endo-3-methylbicyclo[2.2.1]hept-endo-2-yl)methyl]bicyclo[2.2.1]heptane and endo-2-methyl-exo-3-methyl-exo-2-[(endo-2-methylbicyclo[2.2.1]hept-endo-3-yl)methyl]bicyclo[2.2.1]heptane and endo-2-methyl-exo-3-methyl-exo-2-[(exo-3-methylbicyclo[2.2.1]hept-exo-2-yl)methyl]bicyclo[2.2.1]heptane and endo-2-methyl-exo-3-methyl-exo-2-[(exo-2-methylbicyclo[2.2.1]hept-exo-3-yl)methyl]bicyclo[2.2.1]heptane
EC number: 939-299-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to attached justification for read across.
- Reason / purpose for cross-reference:
- read-across source
- Vehicle:
- no
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.21 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks:
- estimated from limit of quantification
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.21 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks:
- estimated from limit of quantification
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.21 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks:
- estimated from limit of quantification
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.21 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks:
- estimated from limit of quantification
- Basis for effect:
- biomass
- Details on results:
- In unfiltered samples of test cultures, the measured concentrations of T-12 ranged from 84.4 mg/L at the start to 79.2 mg/L after 72 hours. The concentrations of T-12 in filtered samples were below the limit of accurate quantification of the available analytical method (<0.210 mg/L) on both occasions of analysis. Although the concentration of dissolved T-12 to which the algae were exposed could not be identified, a condition of maximum attainable exposure is considered to have been employed.
Cell numbers were counted daily to monitor growth. The test results are expressed in terms of the area under the growth curve and growth rate. At a nominal concentration of 100 mg/L, the reductions in these values during the study were, at most, only 2% compared to the control cultures.
Consequently, neither the 72-hour median effect concentrations (EbC50 and E,C50) nor the no observed effect concentration (NOEC) were identified but must be greater than limit of quantification of the test substance in test medium. - Results with reference substance (positive control):
- The results of the most recent laboratory reference test using potassium dichromate indicated that its 72-hour EbC50 to Selenastrum capricornutum was 0.52 mg/L; this was within the range typically obtained in this laboratory (0.3 to 1 mg/L).
- Reported statistics and error estimates:
- None required
- Validity criteria fulfilled:
- yes
- Remarks:
- Although the concentration of dissolved T-12 to which the algae were exposed could not be identified, a condition of maximum attainable exposure is considered to have been employed.
- Conclusions:
- T-12 was not found to be inhibitory to Selenastrum capricornutum when dispersed in algal nutrient medium at concentrations greatly in excess of its limit of aqueous solubility.
Reference
Nominal T-12 concentration |
Cell densities (x104cells/ml) |
||
24 hours |
48 hours |
72 hours |
|
Control R1 R2 R3 R4 R5 R6
Mean |
9.12 7.62 6.28 7.21 7.05 6.33
7.27 |
33.9 24.1 28.0 28.5 26.5 26.6
27.9 |
113 67.4 137 137 125 121
117 |
100 mg/ml R1 R2 R3 R4 R5 R6
Mean |
10.5 9.14 9.32 9.92 9.85 9.10
9.64 |
37.4 33.4 24.8 31.7 31.0 29.6
31.3 |
94.6 104 113 87.0 116 117
105 |
R1 – R6 Replicates 1 -6
Description of key information
The test substance, T-12, an analogue of the registered substance T-13h, was not found to be inhibitory to Selenastrum capricornutum when dispersed in algal nutrient medium at concentrations greatly in excess of its limit of aqueous solubility.
Key value for chemical safety assessment
Additional information
The toxicity of T-12 to aquatic algae was determined by HLS, 1998, Report No.: IDK0064. The study was conducted in accordance with OECD Method 201 and EU method C3 and was considered reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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