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Diss Factsheets
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EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1943
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Cases on the Thoracic Surgical Unit at Harefield
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 943
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- SULPHAPYRIDINE
- IUPAC Name:
- SULPHAPYRIDINE
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- No data
Constituent 1
Results and discussion
Any other information on results incl. tables
Up to 10 g. of sulphapyridine powder placed in the pleural cavity at operation has, in 22 cases, barely and infrequently led to therapeutic levels of the drug in the blood. The maximum level reached was 5.5 mg. per 100 c.cm. This compared with maxima of 10 mg. per 100 c.cm. often reached after the intraperitoneal administration of sulphanilamide. The average time for complete excretion of sulphapyridine had been found to be six days, while other workers had found that sulphanilamide was completely excreted in four days when placed intraperitoneally. Absorption of sulphapyridine through the pleura was irregular from case to case, greatly differing amounts of drug being found in both the pleural fluid and the blood at the same times after operation. This was probably due to caking of the powdered drug and the formation of pleural adhesions which interfere with free absorption.
Applicant's summary and conclusion
- Conclusions:
- Absorption of sulphapyridine through the pleura was irregular from case to case, greatly differing amounts of drug being found in both the pleural fluid and the blood at the same times after operation. This was probably due to caking of the powdered drug and the formation of pleural adhesions which interfere with free absorption.
- Executive summary:
Up to 10 g of sulphapyridine powder was administrated in the pleural cavity at operation in 22 cases during 6 days. During the time, the amount of the sulphapyridine was determinded in the blood and pleural fluid.
The maximum level reached was 5.5 mg. per 100 c.cm. This compared with maxima of 10 mg. per 100 c.cm. often reached after the intraperitoneal administration of sulphanilamide. The average time for complete excretion of sulphapyridine had been found to be six days, while other workers had found that sulphanilamide was completely excreted in four days when placed intraperitoneally.
Absorption of sulphapyridine through the pleura was irregular from case to case, greatly differing amounts of drug being found in both the pleural fluid and the blood at the same times after operation. This was probably due to caking of the powdered drug and the formation of pleural adhesions which interfere with free absorption.
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