Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-145-8 | CAS number: 2372-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 07, 1987 to January 27, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine
- EC Number:
- 219-145-8
- EC Name:
- N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine
- Cas Number:
- 2372-82-9
- Molecular formula:
- C18H41N3
- IUPAC Name:
- bis(3-aminopropyl)(dodecyl)amine
- Test material form:
- liquid
- Details on test material:
- - Name of test material: N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine
- Description: Clear, pale straw-coloured, slightly viscous liquid
- Container: Plastic screw-top bottle
- Sponsor's identification: P4150
- Batch number: 130787
- Analytical purity: 30% (concentration of the test substance in vehicle).
- Date of arrival: 17 november 1987
- Storage conditions: Room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Limimted, Wyton, Huntingdon Cambridgeshire
- Age at study initiation: 5-8 weeks
- Assigned to test groups randomly: Yes
- Housing: Up to 5 per cage
- Diet : Ad libitum
- Water: Ad libitum
- Acclimation period: At least 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-22
- Humidity (%): 40-60
- Air changes (per hr): approximately 15 times
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - Concentration in vehicle: 30%
- Doses:
- Dose-range finding study: 500, 1,000, 2,000, 3,000 and 5,000 mg/kg bw (as 30% aqueous solution)
Main study: 250, 500, 1,000, 2,000 mg/kg bw as 30% aqueous solution, (i.e., equivalent to 75, 150, 300, 600 mg a.i./kg bw) - No. of animals per sex per dose:
- 1/sex/dose in the dose-range finding study; 5/sex/dose in the main study.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5 d in the dose-range finding study; 14 d in the main study.
- Frequency of observations and weighing: 1 and 4 h after dosing and then daily. In the dose-range finding study bodyweight was recorded on the day of dosing. In the main study individual bodyweights were recorded on the day of treatment (Day 0), Days 7 and 14 and at death.
- Necropsy of survivors performed: Yes in the main study. In the dose-range finding study no necropsies were performed.
- Other examinations performed: Clinical signs, body weight, gross pathology.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 871 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 704 - 1 076
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 261 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: based on 30% purity
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 933 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 664 - 1 310
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 280 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: based on 30% purity
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 812 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 616 - 1 072
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 243.6 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: based on 30% purity
- Mortality:
- In the dose-range finding study: Both animals survived at the 500 mg/kg bw dose level and one animal at the 1,000 mg/kg bw dose level.
In the main study: All animals dosed at 2,000 mg/kg bw died within 24 h of dosing. Three males and four females dosed at 1,000 mg/kg bw died within 24 h of dosing. - Clinical signs:
- other: All treated animals showed systemic signs of toxicity, such as piloerection, hunched posture and decreased respiratory rate between 1 and 4 h of dosing. Those animals treated at 1,000 and 2,000 mg/kg bw showed additional signs of increased salivation.
- Gross pathology:
- Necropsy findings showed that all animals that died during the study had similar abnormalities in the lungs, liver and kidneys, gastric mucosa and intestines. Surviving animals did not show any abnormalities at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the study conditions, the oral LD50 value for all animals was determined to be 261 mg a.i./kg bw (280 mg a.i./kg bw for males and 243.6 mg a.i./kg bw for females).
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance according to OECD Guideline 401, in compliance with GLP. Groups of 5 male and 5 female Sprague Dawley rats were administered oral gavage doses of a 30% aqueous solution of the test substance at 250, 500, 1000, 2000 mg/kg bw (equivalent to 75, 150, 300, 600 mg a.i./kg bw). Parameters evaluated included survival, clinical observations, bodyweight and necropsy findings in all animals after a 14 day observation period. The LD50 and 95% confidence intervals were calculated separately for males and females using the method of Thompson WR. All animals in the 600 mg a.i./kg bw dose group and 7 of 10 animals (3 males and 4 females) in the 300 mg a.i./kg bw dose group died within 24 h of dosing. All treated animals showed systemic signs of toxicity such as pilo-erection, hunched posture and decreased respiratory rate between 1 and 4 h after dosing. Animals treated at 300 and 600 mg a.i./kg bw showed additional signs of increased salivation. Further, reduced bodyweight gain was observed during the first week after dosing in some animals in the 75 and 150 mg a.i./kg bw dose group and all animals in the 300 mg a.i./kg bw dose group. Necropsy findings showed that all animals that died during the study had similar abnormalities in the lungs, liver and kidneys, gastric mucosa and intestines. Under the study conditions, the oral LD50 value for all animals was determined to be 261 mg a.i./kg bw (280 mg a.i./kg bw for males and 243.6 mg a.i./kg bw for females) (Jones, 1988).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.