chromium yttrium oxide (1:1:3)

Carcinogenicity

Description of key information

Calculations of the carcinogenic potential and carcinogenicity are based  on the structure of  yttrium chromite. The results from structural alerts indicate that yttrium chromite has no carcinogenic effects.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Link to relevant study records

Reference

Endpoint:

carcinogenicity

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Values are predicted from model. Thus, they provide an approximation compared to experimental measure.

Principles of method if other than guideline:

The following models were applied to examine for structural alerts that indicate the carcinogenic potential of yttrium chromite using ChemProp:
Carcinogenic potential
Carcinogenicity by Benigni et al.
Consensus model (Probability for carcinogenicity & weight of evidence for carcinogenicity). The Consensus model combines the output of the individual models that can be used by ChemProp. The lowest possible value is obtained when no model predicts an effect, and the highest possible (0.86) value when all models predict the effect.

Details on results:

Carcinogenic potential (1=active; 0= inactive): 0 - Be aware: No model domain is known!
Carcinogenicity by Benigni et al. (1=active; 0= inactive): 0
Probability for carcinogenicity (0.26 ... 0.86): 0.26
Weight of evidence for carcinogenicity (-4.6 ... 7.9): -4.6

Conclusions:

Calculations of the carcinogenic potential and carcinogenicity were undertaken for yttrium chromite. The calculations are based on the structure of yttrium chromite. The results show that yttrium chromite has no carcinogenic effects.

Executive summary:

We tested for structural alerts and potential for carcinogenicity of yttrium chromite. The estimation is based on various models including the potential of carcinogenicity, the model by Benigni et al. well as the Consensus model , using ChemProp. The potential of carcinogenicity and the carcinogenicity by Benigni et al. are both 0 (1=active; 0= inactive). The results of the Consensus model predict the lowest possible values for probability for carcinogenicity and the weight of evidence of the model. Therefore, we can consider that yttrium chromite has no carcinogenic effects.

Endpoint conclusion

Endpoint conclusion:

no study available (further information necessary)

Carcinogenicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

carcinogenicity

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Values are predicted from model. Thus, they provide an approximation compared to experimental measure.

Principles of method if other than guideline:

The following models were applied to examine for structural alerts that indicate the carcinogenic potential of yttrium chromite using ChemProp:
Carcinogenic potential
Carcinogenicity by Benigni et al.
Consensus model (Probability for carcinogenicity & weight of evidence for carcinogenicity). The Consensus model combines the output of the individual models that can be used by ChemProp. The lowest possible value is obtained when no model predicts an effect, and the highest possible (0.86) value when all models predict the effect.

Details on results:

Carcinogenic potential (1=active; 0= inactive): 0 - Be aware: No model domain is known!
Carcinogenicity by Benigni et al. (1=active; 0= inactive): 0
Probability for carcinogenicity (0.26 ... 0.86): 0.26
Weight of evidence for carcinogenicity (-4.6 ... 7.9): -4.6

Conclusions:

Calculations of the carcinogenic potential and carcinogenicity were undertaken for yttrium chromite. The calculations are based on the structure of yttrium chromite. The results show that yttrium chromite has no carcinogenic effects.

Executive summary:

We tested for structural alerts and potential for carcinogenicity of yttrium chromite. The estimation is based on various models including the potential of carcinogenicity, the model by Benigni et al. well as the Consensus model , using ChemProp. The potential of carcinogenicity and the carcinogenicity by Benigni et al. are both 0 (1=active; 0= inactive). The results of the Consensus model predict the lowest possible values for probability for carcinogenicity and the weight of evidence of the model. Therefore, we can consider that yttrium chromite has no carcinogenic effects.

Endpoint conclusion

Endpoint conclusion:

no study available (further information necessary)

Carcinogenicity: via dermal route

Link to relevant study records

Reference

Endpoint:

carcinogenicity

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Values are predicted from model. Thus, they provide an approximation compared to experimental measure.

Principles of method if other than guideline:

The following models were applied to examine for structural alerts that indicate the carcinogenic potential of yttrium chromite using ChemProp:
Carcinogenic potential
Carcinogenicity by Benigni et al.
Consensus model (Probability for carcinogenicity & weight of evidence for carcinogenicity). The Consensus model combines the output of the individual models that can be used by ChemProp. The lowest possible value is obtained when no model predicts an effect, and the highest possible (0.86) value when all models predict the effect.

Details on results:

Carcinogenic potential (1=active; 0= inactive): 0 - Be aware: No model domain is known!
Carcinogenicity by Benigni et al. (1=active; 0= inactive): 0
Probability for carcinogenicity (0.26 ... 0.86): 0.26
Weight of evidence for carcinogenicity (-4.6 ... 7.9): -4.6

Conclusions:

Calculations of the carcinogenic potential and carcinogenicity were undertaken for yttrium chromite. The calculations are based on the structure of yttrium chromite. The results show that yttrium chromite has no carcinogenic effects.

Executive summary:

We tested for structural alerts and potential for carcinogenicity of yttrium chromite. The estimation is based on various models including the potential of carcinogenicity, the model by Benigni et al. well as the Consensus model , using ChemProp. The potential of carcinogenicity and the carcinogenicity by Benigni et al. are both 0 (1=active; 0= inactive). The results of the Consensus model predict the lowest possible values for probability for carcinogenicity and the weight of evidence of the model. Therefore, we can consider that yttrium chromite has no carcinogenic effects.

Endpoint conclusion

Endpoint conclusion:

no study available (further information necessary)

Justification for classification or non-classification

There is no indication for carcinogenic potential of yttrium chromite, so that the substance is not classified for carcinogenicity.

Additional information

We tested for structural alerts and potential for carcinogenicity of yttrium chromite. The estimation is based on various models including the potential of carcinogenicity, the model by Benigni et al. well as the Consensus model , using ChemProp. The potential of carcinogenicity and the carcinogenicity by Benigni et al. are both 0 (1=active; 0= inactive). The results of the Consensus model predict the lowest possible values for probability for carcinogenicity and the weight of evidence of the model. Therefore, we can consider that yttrium chromite has no carcinogenic effects.